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Mendeley readers
Attention Score in Context
| Title |
Conserved Structural and Sequence Elements Implicated in the Processing of Gene-encoded Circular Proteins*
|
|---|---|
| Published in |
Journal of Biological Chemistry, August 2004
|
| DOI | 10.1074/jbc.m407421200 |
| Pubmed ID | |
| Authors |
Julie L. Dutton, Rosemary F. Renda, Clement Waine, Richard J. Clark, Norelle L. Daly, Cameron V. Jennings, Marilyn A. Anderson, David J. Craik |
| Abstract |
The cyclotides are the largest family of naturally occurring circular proteins. The mechanism by which the termini of these gene-encoded proteins are linked seamlessly with a peptide bond to form a circular backbone is unknown. Here we report cyclotide-encoding cDNA sequences from the plant Viola odorata and compare them with those from an evolutionarily distinct species, Oldenlandia affinis. Individual members of this multigene family encode one to three mature cyclotide domains. These domains are preceded by N-terminal repeat regions (NTRs) that are conserved within a plant species but not between species. We have structurally characterized peptides corresponding to these NTRs and show that, despite them having no sequence homology, they form a structurally conserved alpha-helical motif. This structural conservation suggests a vital role for the NTR in the in vivo folding, processing, or detoxification of cyclotide domains from the precursor protein. |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Unknown | 53 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 22% |
| Researcher | 8 | 15% |
| Student > Bachelor | 6 | 11% |
| Student > Master | 6 | 11% |
| Professor | 3 | 5% |
| Other | 7 | 13% |
| Unknown | 13 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 35% |
| Biochemistry, Genetics and Molecular Biology | 9 | 16% |
| Chemistry | 6 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Mathematics | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 16 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2017.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Journal of Biological Chemistry
#13,968
of 85,240 outputs
Outputs of similar age
#11,419
of 67,249 outputs
Outputs of similar age from Journal of Biological Chemistry
#140
of 817 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85,240 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 817 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.