| Title |
Customization of home closed-loop insulin delivery in adult patients with type 1 diabetes, assisted with structured remote monitoring: the pilot WP7 Diabeloop study
|
|---|---|
| Published in |
Acta Diabetologica, March 2018
|
| DOI | 10.1007/s00592-018-1123-1 |
| Pubmed ID | |
| Authors |
Pierre Yves Benhamou, Erik Huneker, Sylvia Franc, Maeva Doron, Guillaume Charpentier, on behalf of the Diabeloop Consortium |
| Abstract |
Improvement in closed-loop insulin delivery systems could result from customization of settings to individual needs and remote monitoring. This pilot home study evaluated the efficacy and relevance of this approach. A bicentric clinical trial was conducted for 3 weeks, using an MPC-based algorithm (Diabeloop Artificial Pancreas system) featuring five settings designed to modulate the reactivity of regulation. Remote monitoring was ensured by expert nurses with a web platform generating automatic Secured Information Messages (SIMs) and with a structured procedure. Endpoints were glucose metrics and description of impact of monitoring on regulation parameters. Eight patients with type 1 diabetes (six men, age 41.8 ± 11.4 years, HbA1c 7.7 ± 1.0%) were included. Time spent in the 70-180 mg/dl range was 70.2% [67.5; 76.9]. Time in hypoglycemia < 70 mg/dl was 2.9% [2.1; 3.4]. Eleven SIMs led to phone intervention. Original default settings were modified in all patients by the intervention of the nurses. This pilot trial suggests that the Diabeloop closed-loop system could be efficient regarding metabolic outcomes, whereas its telemedical monitoring feature could contribute to enhanced efficacy and safety. This study is registered at ClinicalTrials.gov with trial registration number NCT02987556. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 121 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 11% |
| Student > Bachelor | 13 | 11% |
| Student > Ph. D. Student | 12 | 10% |
| Researcher | 11 | 9% |
| Student > Doctoral Student | 10 | 8% |
| Other | 15 | 12% |
| Unknown | 47 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 25% |
| Engineering | 11 | 9% |
| Nursing and Health Professions | 8 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Psychology | 4 | 3% |
| Other | 13 | 11% |
| Unknown | 51 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2018.
All research outputs
#15,442,893
of 23,026,672 outputs
Outputs from Acta Diabetologica
#547
of 930 outputs
Outputs of similar age
#211,560
of 332,332 outputs
Outputs of similar age from Acta Diabetologica
#11
of 26 outputs
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We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.