| Title |
EFA6A-like antibodies in paraneoplastic encephalitis associated with immature ovarian teratoma: a case report
|
|---|---|
| Published in |
Journal of Neuro-Oncology, June 2006
|
| DOI | 10.1007/s11060-006-9200-7 |
| Pubmed ID | |
| Authors |
Reiji Koide, Toshio Shimizu, Kazunori Koike, Josep Dalmau |
| Abstract |
We describe a 19-year-old patient with paraneoplastic encephalitis associated with immature ovarian teratoma (OT), who presented with psychiatric symptoms, prolonged disturbance of consciousness, refractory status epilepticus, central hypoventilation, and various abnormal involuntary movements. Immunological characterization of the patient's serum and cerebrospinal fluid (CSF) demonstrated the presence of an autoantibody that colocalized with EFA6A, a brain-specific protein involved in the regulation of dendritic development of hippocampal neurons. Despite the severity of the symptoms, the patient showed significant neurological improvement following removal of the tumor and chemotherapy. This case suggests that physicians should rule out an OT in young women with encephalitis who present with the subacute-onset of psychiatric symptoms. Antibodies that colocalize with EFA6A are a valuable marker for early diagnosis of a potentially reversible paraneoplastic encephalitis associated with OT. |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 6% |
| Mexico | 1 | 3% |
| Unknown | 31 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 24% |
| Student > Doctoral Student | 5 | 15% |
| Other | 3 | 9% |
| Student > Postgraduate | 3 | 9% |
| Student > Ph. D. Student | 3 | 9% |
| Other | 6 | 18% |
| Unknown | 6 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 44% |
| Neuroscience | 5 | 15% |
| Agricultural and Biological Sciences | 1 | 3% |
| Psychology | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 11 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2017.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from Journal of Neuro-Oncology
#1,041
of 2,966 outputs
Outputs of similar age
#22,573
of 64,157 outputs
Outputs of similar age from Journal of Neuro-Oncology
#3
of 12 outputs
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