| Title |
Sex Differences in HIV Infection
|
|---|---|
| Published in |
Current HIV/AIDS Reports, March 2018
|
| DOI | 10.1007/s11904-018-0383-2 |
| Pubmed ID | |
| Authors |
Eileen P. Scully |
| Abstract |
This review will outline the multilevel effects of biological sex on HIV acquisition, pathogenesis, treatment response, and prospects for cure. Potential mechanisms will be discussed along with future research directions. HIV acquisition risk is modified by sex hormones and the vaginal microbiome, with the latter acting through both inflammation and local metabolism of pre-exposure prophylaxis drugs. Female sex associates with enhanced risk for non-AIDS morbidities including cardiovascular and cerebrovascular disease, suggesting different inflammatory profiles in men and women. Data from research on HIV cure points to sex differences in viral reservoir dynamics and a direct role for sex hormones in latency maintenance. Biological sex remains an important variable in determining the risk of HIV infection and subsequent viral pathogenesis, and emerging data suggest sex differences relevant to curative interventions. Recruitment of women in HIV clinical research is a pathway to both optimize care for women and to identify novel therapeutics for use in both men and women. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 33% |
| Portugal | 3 | 17% |
| Canada | 1 | 6% |
| South Africa | 1 | 6% |
| Unknown | 7 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 72% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
| Scientists | 1 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
| Unknown | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 158 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 15% |
| Student > Ph. D. Student | 17 | 11% |
| Researcher | 17 | 11% |
| Student > Master | 14 | 9% |
| Student > Doctoral Student | 8 | 5% |
| Other | 21 | 13% |
| Unknown | 58 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 20% |
| Biochemistry, Genetics and Molecular Biology | 15 | 9% |
| Immunology and Microbiology | 10 | 6% |
| Nursing and Health Professions | 9 | 6% |
| Agricultural and Biological Sciences | 7 | 4% |
| Other | 20 | 13% |
| Unknown | 65 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2023.
All research outputs
#1,805,874
of 24,378,020 outputs
Outputs from Current HIV/AIDS Reports
#31
of 452 outputs
Outputs of similar age
#39,594
of 335,894 outputs
Outputs of similar age from Current HIV/AIDS Reports
#4
of 18 outputs
Altmetric has tracked 24,378,020 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 452 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,894 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.