Title |
Risk of stroke in patients with dengue fever: a population-based cohort study
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Published in |
Canadian Medical Association Journal, March 2018
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DOI | 10.1503/cmaj.170994 |
Pubmed ID | |
Authors |
Hao-Ming Li, Ying-Kai Huang, Yuan-Chih Su, Chia-Hung Kao |
Abstract |
Stroke is a severe neurologic complication of dengue fever, described in only a few case reports. The incidence and risk factors for stroke in patients with dengue remain unclear. We conducted a population-based retrospective cohort study to investigate the risk of stroke in patients with dengue. Using data from the Taiwan National Health Insurance Research Database, we included a total of 13 787 patients with dengue newly diagnosed between 2000 and 2012. The control cohort consisted of patients who did not have dengue, matched 1:1 by demographic characteristics and stroke-related comorbidities. We calculated the cumulative incidences and hazard ratios (HRs) of stroke in both cohorts using Kaplan-Meier curves and Cox proportional hazards regression. The overall incidence rate of stroke was 5.33 per 1000 person-years in the dengue cohort and 3.72 per 1000 person-years in the control cohort, with an adjusted HR of 1.16 (95% confidence interval [CI] 1.01-1.32). The risk of stroke among patients with dengue was highest in the first 2 months after diagnosis (25.53 per 1000 person-years, adjusted HR 2.49, 95% CI 1.48-4.18). Dengue fever was associated with an increased risk of stroke in the first few months after diagnosis. The effect of dengue on stroke may be acute rather than chronic. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 5 | 31% |
United States | 3 | 19% |
Australia | 1 | 6% |
United Kingdom | 1 | 6% |
Brazil | 1 | 6% |
Bolivia, Plurinational State of | 1 | 6% |
Unknown | 4 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 50% |
Practitioners (doctors, other healthcare professionals) | 5 | 31% |
Scientists | 2 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 18% |
Student > Master | 6 | 11% |
Lecturer | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Student > Bachelor | 4 | 7% |
Other | 12 | 21% |
Unknown | 15 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 32% |
Nursing and Health Professions | 4 | 7% |
Agricultural and Biological Sciences | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Other | 6 | 11% |
Unknown | 20 | 36% |