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Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis

Overview of attention for article published in Cell Stress and Chaperones, February 2018
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Title
Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis
Published in
Cell Stress and Chaperones, February 2018
DOI 10.1007/s12192-018-0884-3
Pubmed ID
Authors

Erik G. Marklund, Yichen Zhang, Eman Basha, Justin L. P. Benesch, Elizabeth Vierling

Abstract

The canonical function of small heat-shock proteins (sHSPs) is to interact with proteins destabilized under conditions of cellular stress. While the breadth of interactions made by many sHSPs is well-known, there is currently little knowledge about what structural features of the interactors form the basis for their recognition. Here, we have identified 83 in vivo interactors of the sole sHSP in the cyanobacterium Synechocystis sp. PCC 6803, HSP16.6, reflective of stable associations with soluble proteins made under heat-shock conditions. By performing bioinformatic analyses on these interactors, we identify primary and secondary structural elements that are enriched relative to expectations from the cyanobacterial genome. In addition, by examining the Synechocystis interactors and comparing them with those identified to bind sHSPs in other prokaryotes, we show that sHSPs associate with specific proteins and biological processes. Our data are therefore consistent with a picture of sHSPs being broadly specific molecular chaperones that act to protect multiple cellular pathways.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 33%
Researcher 2 17%
Student > Master 2 17%
Unknown 4 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 33%
Agricultural and Biological Sciences 2 17%
Computer Science 1 8%
Medicine and Dentistry 1 8%
Unknown 4 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2018.
All research outputs
#20,674,485
of 25,394,764 outputs
Outputs from Cell Stress and Chaperones
#495
of 699 outputs
Outputs of similar age
#268,806
of 343,948 outputs
Outputs of similar age from Cell Stress and Chaperones
#10
of 15 outputs
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So far Altmetric has tracked 699 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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