| Title |
Medication neurotoxicity in children
|
|---|---|
| Published in |
Pediatric Radiology, July 2011
|
| DOI | 10.1007/s00247-011-2191-3 |
| Pubmed ID | |
| Authors |
Ramesh S. Iyer, Apeksha Chaturvedi, Sumit Pruthi, Paritosh C. Khanna, Gisele E. Ishak |
| Abstract |
Medication neurotoxicity may have a variety of imaging manifestations in children. In this pictorial essay, we review the two most common brain injury patterns, posterior reversible encephalopathy syndrome (PRES) and acute toxic leukoencephalopathy (ATL). Proposed etiologies, salient features on neurological imaging, and methods for differentiating these entities and their implications will be discussed. Certain agents do not fall into these two broad patterns but instead characteristically involve central structures. We individually review several medications and their respective neurotoxic appearances including methotrexate, cyclosporine A, tacrolimus, metronidazole and vigabatrin. Diagnosis of medication neurotoxicity may be achieved by the combination of new-onset neurological deficits, recent initiation of a new therapy agent and distinctive findings on magnetic resonance imaging. Clinical and radiological improvement and/or resolution are frequently observed after the agent is discontinued. |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 2% |
| Unknown | 44 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 13% |
| Student > Master | 6 | 13% |
| Student > Ph. D. Student | 5 | 11% |
| Student > Postgraduate | 4 | 9% |
| Student > Bachelor | 3 | 7% |
| Other | 12 | 27% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 44% |
| Nursing and Health Professions | 5 | 11% |
| Neuroscience | 3 | 7% |
| Psychology | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 3 | 7% |
| Unknown | 10 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2021.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from Pediatric Radiology
#646
of 2,078 outputs
Outputs of similar age
#42,089
of 119,297 outputs
Outputs of similar age from Pediatric Radiology
#2
of 16 outputs
Altmetric has tracked 22,787,797 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,078 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.