| Title |
Current Research on the Immune Response to Experimental Sporotrichosis
|
|---|---|
| Published in |
Mycopathologia, February 2009
|
| DOI | 10.1007/s11046-009-9190-z |
| Pubmed ID | |
| Authors |
Iracilda Zeppone Carlos, Micheli Fernanda Sassá, Diana Bridon da Graça Sgarbi, Marisa Campos Polesi Placeres, Danielle Cardoso Geraldo Maia |
| Abstract |
Sporotrichosis is often manifested as a chronic granulomatous infection and the monocytes/macrophages play a central role in the host defense system. Surface components of Sporothrix schenckii have been characterized and suggestions have been made as to their possible role in pathogenicity. Ergosterol peroxide, cell-wall compounds (alkali-insoluble fraction-F1 and lipid extract-LEY), and exoantigen from the yeast form of the fungus have been characterized as virulence factors, activating both innate, by cytotoxins linked to the activation of reactive oxygen and nitrogen species (H2O2 and NO), and adaptive immune response to produce cytokines Th1 and Th2 profile. In this study, preliminary results have demonstrated that, in systemic sporotrichosis, TLR-4 triggers the innate immune response, activating an oxidative burst. These data represent the first report of the participation of TLR-4 in murine sporotrichosis, in the presence of lipids from the cell wall of S. schenckii. These results taken together may open new perspectives of study leading to an antifungal agent that could be used to benefit the entire population. |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 54 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 18% |
| Student > Postgraduate | 5 | 9% |
| Student > Ph. D. Student | 5 | 9% |
| Student > Doctoral Student | 4 | 7% |
| Researcher | 4 | 7% |
| Other | 12 | 21% |
| Unknown | 16 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 29% |
| Biochemistry, Genetics and Molecular Biology | 5 | 9% |
| Medicine and Dentistry | 5 | 9% |
| Immunology and Microbiology | 5 | 9% |
| Veterinary Science and Veterinary Medicine | 4 | 7% |
| Other | 4 | 7% |
| Unknown | 17 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2013.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from Mycopathologia
#209
of 1,074 outputs
Outputs of similar age
#33,001
of 93,957 outputs
Outputs of similar age from Mycopathologia
#1
of 4 outputs
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So far Altmetric has tracked 1,074 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
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