| Title |
Regulation of c-fos and c-jun Expression by Calcitonin in Human Breast Cancer Cells
|
|---|---|
| Published in |
Calcified Tissue International, July 1997
|
| DOI | 10.1007/s002239900273 |
| Pubmed ID | |
| Authors |
M. Lacroix, J. J. Body |
| Abstract |
Breast cancer cells (BCC) have calcitonin (CT) receptors, yet the action of the hormone on these cells is largely unknown. We found that CT produced a strong and transient time- and dose-dependent increase in c-fos mRNA in BCC lines. This event was prevented by a protein kinase A (PKA) inhibitor, H89. CT alone did not influence the expression of c-jun and of the tissue inhibitors of metalloproteases (timp) -1 and -2 mRNAs; however, it reduced the induction of these mRNAs by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA), without apparent changes in the half-life of the mRNA (measured for c-jun). Along the same line, CT reduced the c-jun induction and T-47D growth stimulation by epidermal growth factor (EGF) and insulin. These effects were mimicked by forskolin and/or prevented by H89, suggesting that PKA activation was involved. These results indicate that CT modulates in BCC the mRNA levels of two important growth-related early response genes (c-fos and c-jun) and of two other genes (timp-1 and -2) involved in the control of metastatic events. |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 3 | 60% |
| Student > Master | 1 | 20% |
| Unknown | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 40% |
| Social Sciences | 1 | 20% |
| Agricultural and Biological Sciences | 1 | 20% |
| Unknown | 1 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2008.
All research outputs
#8,513,013
of 25,382,250 outputs
Outputs from Calcified Tissue International
#593
of 1,887 outputs
Outputs of similar age
#9,438
of 29,170 outputs
Outputs of similar age from Calcified Tissue International
#3
of 8 outputs
Altmetric has tracked 25,382,250 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,887 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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