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Mendeley readers
Attention Score in Context
| Title |
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
|
|---|---|
| Published in |
Nature Genetics, November 2009
|
| DOI | 10.1038/ng.483 |
| Pubmed ID | |
| Authors |
Peter Donnelly, Leena Peltonen, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Nicholas Craddock, Panos Deloukas, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Mark I McCarthy, Colin N A Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Nilesh Samani, Richard C Trembath, Ananth C Viswanathan, Nicholas Wood, Chris C A Spencer, Jeffrey C Barrett, Céline Bellenguez, Daniel Davison, Colin Freeman, Amy Strange, Peter Donnelly, Cordelia Langford, Sarah E Hunt, Sarah Edkins, Rhian Gwilliam, Hannah Blackburn, Suzannah J Bumpstead, Serge Dronov, Matthew Gillman, Emma Gray, Naomi Hammond, Alagurevathi Jayakumar, Owen T McCann, Jennifer Liddle, Marc L Perez, Simon C Potter, Radhi Ravindrarajah, Michelle Ricketts, Matthew Waller, Paul Weston, Sara Widaa, Pamela Whittaker, Panos Deloukas, Leena Peltonen, Christopher G Mathew, Jenefer M Blackwell, Matthew A Brown, Aiden Corvin, Mark I McCarthy, Chris C A Spencer, Antony P Attwood, Jonathan Stephens, Jennifer Sambrook, Willem H Ouwehand, Wendy L McArdle, Susan M Ring, David P Strachan |
| Abstract |
Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 cases and 5,417 controls. Loci showing evidence of association at P < 1 x 10(-5) were followed up by genotyping in an independent set of 2,321 cases and 4,818 controls. We find genome-wide significant evidence of association at three new loci, each containing at least one biologically relevant candidate gene, on chromosomes 20q13 (HNF4A; P = 3.2 x 10(-17)), 16q22 (CDH1 and CDH3; P = 2.8 x 10(-8)) and 7q31 (LAMB1; P = 3.0 x 10(-8)). Of note, CDH1 has recently been associated with susceptibility to colorectal cancer, an established complication of longstanding ulcerative colitis. The new associations suggest that changes in the integrity of the intestinal epithelial barrier may contribute to the pathogenesis of ulcerative colitis. |
Mendeley readers
The data shown below were compiled from readership statistics for 436 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 7 | 2% |
| Germany | 4 | <1% |
| United States | 4 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 418 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 97 | 22% |
| Student > Ph. D. Student | 83 | 19% |
| Student > Bachelor | 40 | 9% |
| Student > Master | 39 | 9% |
| Student > Doctoral Student | 27 | 6% |
| Other | 78 | 18% |
| Unknown | 72 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 127 | 29% |
| Medicine and Dentistry | 90 | 21% |
| Biochemistry, Genetics and Molecular Biology | 75 | 17% |
| Immunology and Microbiology | 19 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 2% |
| Other | 33 | 8% |
| Unknown | 84 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2023.
All research outputs
#2,020,983
of 25,837,817 outputs
Outputs from Nature Genetics
#2,699
of 7,639 outputs
Outputs of similar age
#6,287
of 108,038 outputs
Outputs of similar age from Nature Genetics
#15
of 52 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,038 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.