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Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1*

Overview of attention for article published in Journal of Biological Chemistry, April 2002
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

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30 patents
wikipedia
5 Wikipedia pages

Citations

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585 Dimensions

Readers on

mendeley
239 Mendeley
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1 Connotea
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Title
Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1*
Published in
Journal of Biological Chemistry, April 2002
DOI 10.1074/jbc.m202390200
Pubmed ID
Authors

Valérie Schreiber, Jean-Christophe Amé, Pascal Dollé, Inès Schultz, Bruno Rinaldi, Valérie Fraulob, Josiane Ménissier-de Murcia, Gilbert de Murcia

Abstract

The DNA damage dependence of poly(ADP-ribose) polymerase-2 (PARP-2) activity is suggestive of its implication in genome surveillance and protection. Here we show that the PARP-2 gene, mainly expressed in actively dividing tissues follows, but to a smaller extent, that of PARP-1 during mouse development. We found that PARP-2 and PARP-1 homo- and heterodimerize; the interacting interfaces, sites of reciprocal modification, have been mapped. PARP-2 was also found to interact with three other proteins involved in the base excision repair pathway: x-ray cross complementing factor 1 (XRCC1), DNA polymerase beta, and DNA ligase III, already known as partners of PARP-1. XRCC1 negatively regulates PARP-2 activity, as it does for PARP-1, while being a polymer acceptor for both PARP-1 and PARP-2. To gain insight into the physiological role of PARP-2 in response to genotoxic stress, we developed by gene disruption mice deficient in PARP-2. Following treatment by the alkylating agent N-nitroso-N-methylurea (MNU), PARP-2-deficient cells displayed an important delay in DNA strand breaks resealing, similar to that observed in PARP-1 deficient cells, thus confirming that PARP-2 is also an active player in base excision repair despite its low capacity to synthesize ADP-ribose polymers.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 239 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 1%
United States 3 1%
India 1 <1%
Ireland 1 <1%
Unknown 231 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 67 28%
Student > Master 34 14%
Student > Bachelor 28 12%
Researcher 27 11%
Student > Doctoral Student 12 5%
Other 33 14%
Unknown 38 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 81 34%
Biochemistry, Genetics and Molecular Biology 66 28%
Medicine and Dentistry 26 11%
Chemistry 7 3%
Neuroscience 5 2%
Other 10 4%
Unknown 44 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2023.
All research outputs
#3,798,066
of 25,371,288 outputs
Outputs from Journal of Biological Chemistry
#6,156
of 85,238 outputs
Outputs of similar age
#8,339
of 128,719 outputs
Outputs of similar age from Journal of Biological Chemistry
#54
of 879 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85,238 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 128,719 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 879 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.