| Title |
Extended and bent conformations of the mannose receptor family
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, January 2008
|
| DOI | 10.1007/s00018-007-7497-9 |
| Pubmed ID | |
| Authors |
O. Llorca |
| Abstract |
In mammals, the mannose receptor family consists of four members, Endo180, DEC-205, phospholipase A2 receptor and the mannose receptor. The extracellular domains of all these receptors contain a similar arrangement of domains in which an N-terminal cysteine-rich domain is followed by a single fibronectin type II domain and eight or ten C-type lectin-like domains. This review focuses on the three-dimensional structure of the receptors in the mannose receptor family and its functional implication. Recent research has revealed that several members of this family can exist in at least two configurations: an extended conformation with the N-terminal cysteine-rich domain pointing outwards from the cell membrane and a bent conformation where the N-terminal domains fold back to interact with C-type lectin-like domains at the middle of the structure. Conformational transitions between these two states seem to regulate the interaction of these receptors with ligands and their oligomerization. |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Denmark | 1 | 2% |
| France | 1 | 2% |
| Unknown | 54 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 21% |
| Student > Ph. D. Student | 9 | 16% |
| Student > Master | 7 | 12% |
| Student > Bachelor | 6 | 11% |
| Student > Postgraduate | 5 | 9% |
| Other | 12 | 21% |
| Unknown | 6 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 40% |
| Medicine and Dentistry | 13 | 23% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Chemistry | 3 | 5% |
| Engineering | 2 | 4% |
| Other | 3 | 5% |
| Unknown | 5 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2014.
All research outputs
#7,845,540
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,655
of 4,151 outputs
Outputs of similar age
#43,162
of 160,628 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#16
of 32 outputs
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