| Title |
An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, March 2018
|
| DOI | 10.1007/s10803-018-3536-7 |
| Pubmed ID | |
| Authors |
Alan S. Lewis, Gerrit Ian van Schalkwyk, Mayra Ortiz Lopez, Fred R. Volkmar, Marina R. Picciotto, Denis G. Sukhodolsky |
| Abstract |
Nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. |
X Demographics
The data shown below were collected from the profiles of 54 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 26% |
| United Kingdom | 4 | 7% |
| Spain | 3 | 6% |
| Australia | 3 | 6% |
| Germany | 2 | 4% |
| Canada | 2 | 4% |
| Netherlands | 1 | 2% |
| Finland | 1 | 2% |
| South Africa | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 20 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 48 | 89% |
| Scientists | 4 | 7% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 99 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 12% |
| Student > Master | 11 | 11% |
| Student > Doctoral Student | 9 | 9% |
| Researcher | 7 | 7% |
| Student > Bachelor | 5 | 5% |
| Other | 12 | 12% |
| Unknown | 43 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 23 | 23% |
| Medicine and Dentistry | 11 | 11% |
| Neuroscience | 6 | 6% |
| Social Sciences | 3 | 3% |
| Business, Management and Accounting | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 49 | 49% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2024.
All research outputs
#1,452,189
of 25,870,142 outputs
Outputs from Journal of Autism and Developmental Disorders
#544
of 5,459 outputs
Outputs of similar age
#31,570
of 354,589 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#13
of 122 outputs
Altmetric has tracked 25,870,142 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,459 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,589 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 122 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.