| Title |
Maturation of the QT Variability Index is Impaired in Preterm Infants
|
|---|---|
| Published in |
Pediatric Cardiology, March 2018
|
| DOI | 10.1007/s00246-018-1839-2 |
| Pubmed ID | |
| Authors |
Arisa Kojima, Tadayoshi Hata, Tsuneaki Sadanaga, Yuri Mizutani, Hidetoshi Uchida, Yuri Kawai, Masahiko Manabe, Masayuki Fujino, Yoshihiko Eryu, Hiroko Boda, Masafumi Miyata, Tetsushi Yoshikawa |
| Abstract |
Reduced heart rate (HR) variability in preterm infants compared with full-term infants suggests that autonomic cardiac control is developmentally delayed. However, the association between developmental changes in myocardial repolarization and gestational age remains unknown. This study investigated the association between the myocardial repolarization lability index, namely the QT variability index (QTVI) = log10 [(QTv/QTm2)/(HRv/HRm2)], and the perinatal profile of healthy 1-month-old infants. We included 209 infants (143 boys and 87 girls; mean gestational weeks at birth, 38.6 ± 1.7) who were born in university hospitals between 2014 and 2015 without apparent cardiac disease. We compared the ECG variability indices in 28 infants born before 37 gestational weeks (mean gestational weeks at birth, 35.6 ± 1.1 as preterm) and 181 infants born at the average number of gestational weeks (mean gestational weeks at birth, 38.8 ± 1.1 as controls). There was a negative correlation between the QTVI and gestational weeks (r = - 0.460, p = 0.035). QTVI values in preterm infants were larger than those in the controls (0.01 ± 0.50 vs. -0.26 ± 0.48, p = 0.023). In conclusion, the QTVI is negatively correlated with gestational age. The QTVI can serve as an index of the maturity of the cardiac autonomic nervous system and myocardial depolarization. |
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| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
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| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 21% |
| Other | 2 | 14% |
| Student > Postgraduate | 2 | 14% |
| Student > Master | 1 | 7% |
| Student > Doctoral Student | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 5 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 21% |
| Engineering | 2 | 14% |
| Sports and Recreations | 1 | 7% |
| Neuroscience | 1 | 7% |
| Psychology | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 6 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2018.
All research outputs
#20,468,008
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Outputs from Pediatric Cardiology
#1,103
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Outputs of similar age
#293,923
of 332,696 outputs
Outputs of similar age from Pediatric Cardiology
#29
of 38 outputs
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