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Attention Score in Context
| Title |
A high-density association screen of 155 ion transport genes for involvement with common migraine
|
|---|---|
| Published in |
Human Molecular Genetics, August 2008
|
| DOI | 10.1093/hmg/ddn227 |
| Pubmed ID | |
| Authors |
Dale R. Nyholt, K. Steven LaForge, Mikko Kallela, Kirsi Alakurtti, Verneri Anttila, Markus Färkkilä, Eija Hämaläinen, Jaakko Kaprio, Mari A. Kaunisto, Andrew C. Heath, Grant W. Montgomery, Hartmut Göbel, Unda Todt, Michel D. Ferrari, Lenore J. Launer, Rune R. Frants, Gisela M. Terwindt, Boukje de Vries, W.M. Monique Verschuren, Jan Brand, Tobias Freilinger, Volker Pfaffenrath, Andreas Straube, Dennis G. Ballinger, Yiping Zhan, Mark J. Daly, David R. Cox, Martin Dichgans, Arn M.J.M. van den Maagdenberg, Christian Kubisch, Nicholas G. Martin, Maija Wessman, Leena Peltonen, Aarno Palotie |
| Abstract |
The clinical overlap between monogenic Familial Hemiplegic Migraine (FHM) and common migraine subtypes, and the fact that all three FHM genes are involved in the transport of ions, suggest that ion transport genes may underlie susceptibility to common forms of migraine. To test this leading hypothesis, we examined common variation in 155 ion transport genes using 5257 single nucleotide polymorphisms (SNPs) in a Finnish sample of 841 unrelated migraine with aura cases and 884 unrelated non-migraine controls. The top signals were then tested for replication in four independent migraine case-control samples from the Netherlands, Germany and Australia, totalling 2835 unrelated migraine cases and 2740 unrelated controls. SNPs within 12 genes (KCNB2, KCNQ3, CLIC5, ATP2C2, CACNA1E, CACNB2, KCNE2, KCNK12, KCNK2, KCNS3, SCN5A and SCN9A) with promising nominal association (0.00041 < P < 0.005) in the Finnish sample were selected for replication. Although no variant remained significant after adjusting for multiple testing nor produced consistent evidence for association across all cohorts, a significant epistatic interaction between KCNB2 SNP rs1431656 (chromosome 8q13.3) and CACNB2 SNP rs7076100 (chromosome 10p12.33) (pointwise P = 0.00002; global P = 0.02) was observed in the Finnish case-control sample. We conclude that common variants of moderate effect size in ion transport genes do not play a major role in susceptibility to common migraine within these European populations, although there is some evidence for epistatic interaction between potassium and calcium channel genes, KCNB2 and CACNB2. Multiple rare variants or trans-regulatory elements of these genes are not ruled out. |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ethiopia | 1 | 1% |
| Denmark | 1 | 1% |
| Norway | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 79 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 27% |
| Student > Ph. D. Student | 16 | 19% |
| Student > Master | 8 | 10% |
| Student > Bachelor | 6 | 7% |
| Professor | 5 | 6% |
| Other | 20 | 24% |
| Unknown | 6 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 30% |
| Medicine and Dentistry | 23 | 28% |
| Neuroscience | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Psychology | 5 | 6% |
| Other | 3 | 4% |
| Unknown | 12 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2023.
All research outputs
#5,611,796
of 25,837,817 outputs
Outputs from Human Molecular Genetics
#2,464
of 8,398 outputs
Outputs of similar age
#19,950
of 101,543 outputs
Outputs of similar age from Human Molecular Genetics
#13
of 59 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,398 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 101,543 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.