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Mendeley readers
| Title |
Determination of Glycyrrhizin in Dog Plasma by Liquid Chromatography—Mass Spectrometry and its Application in Pharmacokinetic Studies
|
|---|---|
| Published in |
European Journal of Mass Spectrometry, February 2010
|
| DOI | 10.1255/ejms.1101 |
| Pubmed ID | |
| Authors |
Weichao Ren, Yang Lu, Jing Jing, Jing Zhu, Di Wan, Di Zhao, Jianheng Zheng, Fang Fang, Yan He, Xijing Chen |
| Abstract |
A sensitive liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) method was established and validated for the determination of glycyrrhizin in dog plasma. After treatment with methanol to precipitate proteins, plasma samples were analyzed on a reversed-phase C18 (ODS) column with a mobile phase of methanol:1% formic acid solution (75:25, v/v). MS determination was performed using negative electrospray ionization (negative ESI) in the selected ion monitoring mode. Glycyrrhizin was monitored at the m/z 821 channel and internal standard (gliquidone) at the m/z 526 channel. The calibration curve was linear over the range from 0.05 µg mL(-1) to 10 µg mL(-1) with a correlation coefficient above 0.99. This method was successfully applied to the pharmacokinetic studies in beagle dogs. The absolute bioavailability of glycyrrhizin in beagle dogs was 3.24%. |
Mendeley readers
The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Librarian | 1 | 25% |
| Student > Ph. D. Student | 1 | 25% |
| Student > Doctoral Student | 1 | 25% |
| Unknown | 1 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Computer Science | 2 | 50% |
| Unknown | 2 | 50% |