| Title |
Transcriptome analysis of human gastric cancer
|
|---|---|
| Published in |
Mammalian Genome, December 2005
|
| DOI | 10.1007/s00335-005-0075-2 |
| Pubmed ID | |
| Authors |
Jung-Hwa Oh, Jin Ok Yang, Yoonsoo Hahn, Mi-Rang Kim, Sang-Soon Byun, Yeo-Jin Jeon, Jeong-Min Kim, Kyu-Sang Song, Seung-Moo Noh, Sangsoo Kim, Hyang-Sook Yoo, Yong Sung Kim, Nam-Soon Kim |
| Abstract |
To elucidate the genetic events associated with gastric cancer, 124,704 cDNA clones were collected from 37 human gastric cDNA libraries, including 20 full-length enriched cDNA libraries of gastric cancer cell lines and tissues from Korean patients. An analysis of the collected ESTs revealed that 97,930 high-quality ESTs coalesced into 13,001 clusters, of which 11,135 clusters (85.6%) were annotated to known ESTs. The analysis of the full-length cDNAs also revealed that 4862 clusters (51.7%) contained at least one putative full-length cDNA clone with an initiation codon, with the average length of the 5' UTR of 140 bp. A large number appear to have a diverse transcription start site (TSS). An examination of the TSS of some genes, such as TEGT and GAPD, using 5' RACE revealed that the predicted TSSs are actually found in human gastric cancer cells and that several TSSs differ depending on the specific gastric cell line. Furthermore, of the human gastric ESTs, 766 genes (9.5%) were present as putative alternatively spliced variants. Confirmation of the predicted spliced isoforms using RT-PCR showed that the predicted isoforms exist in gastric cancer cells and some isoforms coexist in gastric cell lines. These results provide potentially useful information for elucidating the molecular mechanisms associated with gastric oncogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 5% |
| Germany | 1 | 2% |
| South Africa | 1 | 2% |
| United Kingdom | 1 | 2% |
| Ukraine | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 34 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 34% |
| Student > Ph. D. Student | 12 | 29% |
| Student > Postgraduate | 3 | 7% |
| Student > Master | 3 | 7% |
| Student > Doctoral Student | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 4 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 44% |
| Biochemistry, Genetics and Molecular Biology | 10 | 24% |
| Medicine and Dentistry | 5 | 12% |
| Neuroscience | 2 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 5 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2023.
All research outputs
#4,879,757
of 23,485,296 outputs
Outputs from Mammalian Genome
#138
of 1,137 outputs
Outputs of similar age
#19,077
of 150,654 outputs
Outputs of similar age from Mammalian Genome
#1
of 9 outputs
Altmetric has tracked 23,485,296 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,137 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 150,654 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them