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Mendeley readers
Attention Score in Context
| Title |
Altered stability of pulmonary surfactant in SP-C-deficient mice
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, May 2001
|
| DOI | 10.1073/pnas.101500298 |
| Pubmed ID | |
| Authors |
Stephan W. Glasser, Michael S. Burhans, Thomas R. Korfhagen, Cheng-Lun Na, Peter D. Sly, Gary F. Ross, Machiko Ikegami, Jeffrey A. Whitsett |
| Abstract |
The surfactant protein C (SP-C) gene encodes an extremely hydrophobic, 4-kDa peptide produced by alveolar epithelial cells in the lung. To discern the role of SP-C in lung function, SP-C-deficient (-/-) mice were produced. The SP-C (-/-) mice were viable at birth and grew normally to adulthood without apparent pulmonary abnormalities. SP-C mRNA was not detected in the lungs of SP-C (-/-) mice, nor was mature SP-C protein detected by Western blot of alveolar lavage from SP-C (-/-) mice. The levels of the other surfactant proteins (A, B, D) in alveolar lavage were comparable to those in wild-type mice. Surfactant pool sizes, surfactant synthesis, and lung morphology were similar in SP-C (-/-) and SP-C (+/+) mice. Lamellar bodies were present in SP-C (-/-) type II cells, and tubular myelin was present in the alveolar lumen. Lung mechanics studies demonstrated abnormalities in lung hysteresivity (a term used to reflect the mechanical coupling between energy dissipative forces and tissue-elastic properties) at low, positive-end, expiratory pressures. The stability of captive bubbles with surfactant from the SP-C (-/-) mice was decreased significantly, indicating that SP-C plays a role in the stabilization of surfactant at low lung volumes, a condition that may accompany respiratory distress syndrome in infants and adults. |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 92 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 25% |
| Student > Master | 14 | 15% |
| Researcher | 10 | 11% |
| Student > Bachelor | 9 | 10% |
| Professor > Associate Professor | 8 | 9% |
| Other | 18 | 19% |
| Unknown | 11 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 26% |
| Agricultural and Biological Sciences | 19 | 20% |
| Biochemistry, Genetics and Molecular Biology | 15 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Engineering | 5 | 5% |
| Other | 8 | 9% |
| Unknown | 16 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2017.
All research outputs
#8,882,501
of 26,017,215 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#67,601
of 104,451 outputs
Outputs of similar age
#15,119
of 44,028 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#268
of 456 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 104,451 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.5. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 44,028 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 456 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.