| Title |
Advanced analytical strategies for measuring free bioactive milk sugars: from composition and concentrations to human metabolic response
|
|---|---|
| Published in |
Analytical & Bioanalytical Chemistry, March 2018
|
| DOI | 10.1007/s00216-018-0913-1 |
| Pubmed ID | |
| Authors |
Aifric O’Sullivan, Jaime Salcedo, Josep Rubert |
| Abstract |
Our daily food intake provides the nutrients to maintain health. However, in addition to the nutritional values, food can promote health and be beneficial in preventing diseases. Human milk is a unique food source that contains essential nutrients in the right balance and other bioactive factors that make it the ideal food for all healthy term infants. Human milk oligosaccharides (HMOs) play an important role in health, at several levels: acting as prebiotics promoting the growth of beneficial bacterial strains, preventing the growth of pathogenic bacteria in the intestine, and modulating the immune response against bacterial infections. However, despite their biological relevance and the advances made in the analytical field, very few studies have been carried out to better understand HMOs bioactivity mechanisms or to examine human metabolic response to dietary supplementation. This review describes the state-of-the-art of glycomics strategies, recent analytical methods, and future trends for the identification and discovery of bioactive sugars, the known mechanisms of action, and discusses findings of some recent human intervention trials. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 13% |
| Unknown | 7 | 88% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 38% |
| Scientists | 3 | 38% |
| Science communicators (journalists, bloggers, editors) | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 19% |
| Other | 6 | 11% |
| Professor > Associate Professor | 6 | 11% |
| Student > Bachelor | 5 | 9% |
| Student > Master | 5 | 9% |
| Other | 10 | 18% |
| Unknown | 14 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 26% |
| Biochemistry, Genetics and Molecular Biology | 7 | 12% |
| Nursing and Health Professions | 4 | 7% |
| Medicine and Dentistry | 4 | 7% |
| Immunology and Microbiology | 3 | 5% |
| Other | 7 | 12% |
| Unknown | 17 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.
All research outputs
#7,717,825
of 25,382,440 outputs
Outputs from Analytical & Bioanalytical Chemistry
#1,765
of 9,619 outputs
Outputs of similar age
#127,578
of 351,846 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#35
of 201 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 9,619 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,846 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 201 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.