| Title |
In vitro and in vivo characterization of highly purified Human Mesothelioma derived cells
|
|---|---|
| Published in |
BMC Cancer, February 2010
|
| DOI | 10.1186/1471-2407-10-54 |
| Pubmed ID | |
| Authors |
Alice Melotti, Antonio Daga, Daniela Marubbi, Annalisa Zunino, Luciano Mutti, Giorgio Corte |
| Abstract |
Malignant pleural mesothelioma is a rare disease known to be resistant to conventional therapies. A better understanding of mesothelioma biology may provide the rationale for new therapeutic strategies. In this regard, tumor cell lines development has been an important tool to study the biological properties of many tumors. However all the cell lines established so far were grown in medium containing at least 10% serum, and it has been shown that primary cell lines cultured under these conditions lose their ability to differentiate, acquire gene expression profiles that differ from that of tissue specific stem cells or the primary tumor they derive from, and in some cases are neither clonogenic nor tumorigenic. Our work was aimed to establish from fresh human pleural mesothelioma samples cell cultures maintaining tumorigenic properties. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 3% |
| Unknown | 36 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 27% |
| Student > Ph. D. Student | 7 | 19% |
| Student > Bachelor | 3 | 8% |
| Student > Postgraduate | 3 | 8% |
| Student > Doctoral Student | 2 | 5% |
| Other | 5 | 14% |
| Unknown | 7 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 35% |
| Medicine and Dentistry | 9 | 24% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Business, Management and Accounting | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 6 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2010.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from BMC Cancer
#2,059
of 8,290 outputs
Outputs of similar age
#34,705
of 93,944 outputs
Outputs of similar age from BMC Cancer
#19
of 39 outputs
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So far Altmetric has tracked 8,290 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
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