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The sea urchin kinome: A first look

Overview of attention for article published in Developmental Biology, September 2006
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Title
The sea urchin kinome: A first look
Published in
Developmental Biology, September 2006
DOI 10.1016/j.ydbio.2006.08.074
Pubmed ID
Authors

Cynthia A. Bradham, Kathy R. Foltz, Wendy S. Beane, Maria I. Arnone, Francesca Rizzo, James A. Coffman, Arcady Mushegian, Manisha Goel, Julia Morales, Anne-Marie Geneviere, François Lapraz, Anthony J. Robertson, Hemant Kelkar, Mariano Loza-Coll, Ian K. Townley, Michael Raisch, Michelle M. Roux, Thierry Lepage, Christian Gache, David R. McClay, Gerard Manning

Abstract

This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is closer to the Drosophila kinome (239) than the human kinome (518) with respect to total kinase number. However, the diversity of sea urchin kinases is surprisingly similar to humans, since the urchin kinome is missing only 4 of 186 human subfamilies, while Drosophila lacks 24. Thus, the sea urchin kinome combines the simplicity of a non-duplicated genome with the diversity of function and signaling previously considered to be vertebrate-specific. More than half of the sea urchin kinases are involved with signal transduction, and approximately 88% of the signaling kinases are expressed in the developing embryo. These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 1%
Germany 1 1%
Brazil 1 1%
India 1 1%
United Kingdom 1 1%
United States 1 1%
Unknown 87 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 27%
Student > Ph. D. Student 22 24%
Professor > Associate Professor 12 13%
Student > Bachelor 8 9%
Student > Master 8 9%
Other 14 15%
Unknown 4 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 53%
Biochemistry, Genetics and Molecular Biology 26 28%
Environmental Science 2 2%
Computer Science 1 1%
Immunology and Microbiology 1 1%
Other 6 6%
Unknown 8 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2014.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Developmental Biology
#1,895
of 5,557 outputs
Outputs of similar age
#30,605
of 88,710 outputs
Outputs of similar age from Developmental Biology
#18
of 57 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,557 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 88,710 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.