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Mendeley readers
Attention Score in Context
| Title |
Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, January 2009
|
| DOI | 10.1073/pnas.0811965106 |
| Pubmed ID | |
| Authors |
Jovencio Hilario, Ichiro Amitani, Ronald J. Baskin, Stephen C. Kowalczykowski |
| Abstract |
Rad51 protein (Rad51) is central to recombinational repair of double-strand DNA breaks. It polymerizes onto DNA and promotes strand exchange between homologous chromosomes. We visualized the real-time assembly and disassembly of human Rad51 nucleoprotein filaments on double-stranded DNA by single-molecule fluorescence microscopy. Rad51 assembly extends the DNA by approximately 65%. Nucleoprotein filament formation occurs via rapid nucleation followed by growth from these nuclei. Growth does not continue indefinitely, however, and nucleoprotein filaments terminate when approximately 2 mum in length. The dependence of nascent filament formation on Rad51 concentration suggests that 2-3 Rad51 monomers are involved in nucleation. Rad51 nucleoprotein filaments are stable and remain extended when ATP hydrolysis is prevented; however, when permitted, filaments decrease in length as a result of conversion to ADP-bound nucleoprotein complexes and partial protein dissociation. Dissociation of Rad51 from dsDNA is slow and incomplete, thereby rationalizing the need for other proteins that facilitate disassembly. |
Mendeley readers
The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 2 | 1% |
| Japan | 2 | 1% |
| Italy | 1 | <1% |
| Vietnam | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 168 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 48 | 26% |
| Researcher | 43 | 24% |
| Student > Master | 18 | 10% |
| Student > Bachelor | 14 | 8% |
| Professor | 10 | 5% |
| Other | 34 | 19% |
| Unknown | 15 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 66 | 36% |
| Biochemistry, Genetics and Molecular Biology | 59 | 32% |
| Physics and Astronomy | 19 | 10% |
| Chemistry | 12 | 7% |
| Unspecified | 3 | 2% |
| Other | 9 | 5% |
| Unknown | 14 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2022.
All research outputs
#5,225,908
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#46,893
of 101,438 outputs
Outputs of similar age
#28,596
of 180,688 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#307
of 648 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,688 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 648 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.