| Title |
The transcription co-repressor TLE1 interacted with the intracellular region of gp130 through its Q domain
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, March 2002
|
| DOI | 10.1023/a:1014880813692 |
| Pubmed ID | |
| Authors |
Fei Liu, Yin Liu, Demin Li, Yong Zhu, Weiming Ouyang, Xin Xie, Boquan Jin |
| Abstract |
As the common signal transducer for IL-6 family cytokines, gp 130 interacts with various signal molecules. Our previous work found the amino-terminal enhancer of split (AES) molecule interacts with gp130 intracellular region through its conserved glutamine-rich (Q) domain. The Q domain in AES shares high homology with those in the transcription co-repressor transducin-like enhancer of split (TLE) proteins. The yeast two-hybrid assay, gluthione S-transferase fusion protein pull-down assay and immuno-co-precipitation assay indicated that the Q domain of TLE1 is capable of binding gp130 intracellular domain, and the intracellular membrane proximal region of gp 130 containing conserved Box1 and Box2 motifs seemed essential for this interaction. The interaction between gp130 and TLE1 indicated that molecules of TLE family might play a role in gp 130 signaling. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 14% |
| Unknown | 6 | 86% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 2 | 29% |
| Student > Ph. D. Student | 2 | 29% |
| Researcher | 2 | 29% |
| Student > Doctoral Student | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 43% |
| Biochemistry, Genetics and Molecular Biology | 3 | 43% |
| Environmental Science | 1 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2019.
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#8,534,976
of 25,373,627 outputs
Outputs from Molecular and Cellular Biochemistry
#481
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Outputs of similar age
#17,285
of 49,733 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#1
of 5 outputs
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