| Title |
Cannabinoid Receptors, Mental Pain and Suicidal Behavior: a Systematic Review
|
|---|---|
| Published in |
Current Psychiatry Reports, March 2018
|
| DOI | 10.1007/s11920-018-0880-4 |
| Pubmed ID | |
| Authors |
Laura Colino, Javier Herranz-Herrer, Elena Gil-Benito, Teresa Ponte-Lopez, Pablo del Sol-Calderon, Maria Rodrigo-Yanguas, María Gil-Ligero, Antonio J. Sánchez-López, Jose de Leon, Hilario Blasco-Fontecilla |
| Abstract |
The current serotonin-based biological model of suicidal behavior (SB) may be too simplistic. There is emerging evidence that other biomarkers and biological systems may be involved in SB pathophysiology. The literature on the endocannabinoid (EC) systems and SB is limited. The objective of the present article is to review all available information on the relationship between cannabinoid receptors (CB1and CB2receptors), and SB and/or psychological pain. Our review is limited by the small number and heterogeneity of studies identified: (1) an autopsy study describing elevated levels of CB1receptor activity in the prefrontal cortex and suicide in both depression and alcoholism and (2) studies supporting the involvement of both CB1and CB2receptors in the regulation of neuropathic pain and stress-induced analgesia. We conclude that cannabinoid receptors, particularly CB1receptors, may become promising targets for the development of novel therapeutic tools for the treatment of SB. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 9% |
| United Kingdom | 2 | 9% |
| Japan | 1 | 5% |
| France | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 15 | 68% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 95% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 16% |
| Researcher | 11 | 14% |
| Other | 8 | 10% |
| Student > Bachelor | 8 | 10% |
| Student > Ph. D. Student | 6 | 8% |
| Other | 8 | 10% |
| Unknown | 26 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 25% |
| Psychology | 11 | 14% |
| Neuroscience | 10 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Nursing and Health Professions | 2 | 3% |
| Other | 7 | 9% |
| Unknown | 26 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2019.
All research outputs
#2,085,622
of 25,639,676 outputs
Outputs from Current Psychiatry Reports
#258
of 1,287 outputs
Outputs of similar age
#44,229
of 352,526 outputs
Outputs of similar age from Current Psychiatry Reports
#5
of 29 outputs
Altmetric has tracked 25,639,676 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,287 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.9. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,526 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.