| Title |
Quantifying tumor-infiltrating immune cells from transcriptomics data
|
|---|---|
| Published in |
Cancer Immunology, Immunotherapy, March 2018
|
| DOI | 10.1007/s00262-018-2150-z |
| Pubmed ID | |
| Authors |
Francesca Finotello, Zlatko Trajanoski |
| Abstract |
By exerting pro- and anti-tumorigenic actions, tumor-infiltrating immune cells can profoundly influence tumor progression, as well as the success of anti-cancer therapies. Therefore, the quantification of tumor-infiltrating immune cells holds the promise to unveil the multi-faceted role of the immune system in human cancers and its involvement in tumor escape mechanisms and response to therapy. Tumor-infiltrating immune cells can be quantified from RNA sequencing data of human tumors using bioinformatics approaches. In this review, we describe state-of-the-art computational methods for the quantification of immune cells from transcriptomics data and discuss the open challenges that must be addressed to accurately quantify immune infiltrates from RNA sequencing data of human bulk tumors. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 20% |
| Germany | 3 | 10% |
| United Kingdom | 2 | 7% |
| France | 2 | 7% |
| Brazil | 1 | 3% |
| Russia | 1 | 3% |
| Israel | 1 | 3% |
| Ireland | 1 | 3% |
| Spain | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 10 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 21 | 70% |
| Members of the public | 7 | 23% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 422 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 422 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 100 | 24% |
| Student > Ph. D. Student | 75 | 18% |
| Student > Master | 45 | 11% |
| Student > Postgraduate | 26 | 6% |
| Student > Bachelor | 26 | 6% |
| Other | 50 | 12% |
| Unknown | 100 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 121 | 29% |
| Agricultural and Biological Sciences | 52 | 12% |
| Medicine and Dentistry | 40 | 9% |
| Immunology and Microbiology | 31 | 7% |
| Computer Science | 24 | 6% |
| Other | 38 | 9% |
| Unknown | 116 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2022.
All research outputs
#1,428,679
of 25,378,162 outputs
Outputs from Cancer Immunology, Immunotherapy
#40
of 2,980 outputs
Outputs of similar age
#31,734
of 354,178 outputs
Outputs of similar age from Cancer Immunology, Immunotherapy
#3
of 30 outputs
Altmetric has tracked 25,378,162 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,980 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.