| Title |
The effect of different levels of dietary restriction on glucose homeostasis and metabolic memory
|
|---|---|
| Published in |
GeroScience, February 2018
|
| DOI | 10.1007/s11357-018-0011-5 |
| Pubmed ID | |
| Authors |
Stephanie Matyi, Jordan Jackson, Karla Garrett, Sathyaseelan S. Deepa, Archana Unnikrishnan |
| Abstract |
Over the past 50 years, dietary restriction (DR) has been shown to extend the life span of a wide variety of organisms. A hallmark feature of DR is improved glucose homeostasis resulting in increased glucose tolerance and insulin sensitivity of animals ranging from rodents to humans. In this study, we demonstrate the early effects of varying levels of DR on glucose tolerance. Within 10 days of 40% DR, glucose tolerance was significantly improved and by 120 days; 10 and 20% DR also showed enhanced glucose tolerance. All three levels of DR showed reduced adiposity, increased expression of genes involved in fat turnover, and a reduction in the expression for markers of inflammation. Studies have shown that mice fed a DR diet retained metabolic memory in terms of improved glucose tolerance even after DR is discontinued. We show that 40% DR not only has an early effect on glucose tolerance but also maintained it after DR was discontinued for 2 months. Therefore, improvement in glucose tolerance is brought about by all three levels of DR but the metabolic memory is not dose responsive. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 24% |
| Student > Bachelor | 5 | 17% |
| Student > Master | 4 | 14% |
| Lecturer | 2 | 7% |
| Professor | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 4 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 31% |
| Neuroscience | 5 | 17% |
| Agricultural and Biological Sciences | 3 | 10% |
| Medicine and Dentistry | 2 | 7% |
| Social Sciences | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 5 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2018.
All research outputs
#18,507,485
of 23,764,938 outputs
Outputs from GeroScience
#423
of 540 outputs
Outputs of similar age
#242,531
of 332,144 outputs
Outputs of similar age from GeroScience
#2
of 3 outputs
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