| Title |
Nematode sbRNAs: Homologs of Vertebrate Y RNAs
|
|---|---|
| Published in |
Journal of Molecular Evolution, March 2010
|
| DOI | 10.1007/s00239-010-9332-4 |
| Pubmed ID | |
| Authors |
Ilenia Boria, Andreas R. Gruber, Andrea Tanzer, Stephan H. Bernhart, Ronny Lorenz, Michael M. Mueller, Ivo L. Hofacker, Peter F. Stadler |
| Abstract |
Stem-bulge RNAs (sbRNAs) are a group of small, functionally yet uncharacterized noncoding RNAs first described in C. elegans, with a few homologous sequences postulated in C. briggsae. In this study, we report on a comprehensive survey of this ncRNA family in the phylum Nematoda. Employing homology search strategies based on both sequence and secondary structure models and a computational promoter screen we identified a total of 240 new sbRNA homologs. For the majority of these loci we identified both promoter regions and transcription termination signals characteristic for pol-III transcripts. Sequence and structure comparison with known RNA families revealed that sbRNAs are homologs of vertebrate Y RNAs. Most of the sbRNAs show the characteristic Ro protein binding motif, and contain a region highly similar to a functionally required motif for DNA replication previously thought to be unique to vertebrate Y RNAs. The single Y RNA that was previously described in C. elegans, however, does not show this motif, and in general bears the hallmarks of a highly derived family member. |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 2 | 3% |
| Colombia | 1 | 2% |
| Sweden | 1 | 2% |
| United Kingdom | 1 | 2% |
| China | 1 | 2% |
| Japan | 1 | 2% |
| Unknown | 58 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 25% |
| Researcher | 16 | 25% |
| Student > Bachelor | 5 | 8% |
| Professor | 3 | 5% |
| Other | 3 | 5% |
| Other | 10 | 15% |
| Unknown | 12 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 40% |
| Biochemistry, Genetics and Molecular Biology | 20 | 31% |
| Chemistry | 2 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Arts and Humanities | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 13 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2016.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from Journal of Molecular Evolution
#450
of 1,438 outputs
Outputs of similar age
#34,590
of 95,094 outputs
Outputs of similar age from Journal of Molecular Evolution
#2
of 4 outputs
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