| Title |
Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
|
|---|---|
| Published in |
Biogerontology, March 2009
|
| DOI | 10.1007/s10522-009-9221-7 |
| Pubmed ID | |
| Authors |
Alexander Elbaz, Daniel Rivas, Gustavo Duque |
| Abstract |
Age-related bone loss has been associated with high levels of marrow adipogenesis. Estrogens (E2) are known to regulate the differentiation of marrow precursors into osteoblasts, however, their role in bone marrow adipogenesis remain unknown. E2 regulate adipocyte differentiation in subcutaneous and visceral fat through interaction with other nuclear receptors. This interaction has not been assessed in bone marrow adipocytes in vivo. In this study, we compared two groups of animals, young and old, after either oophorectomy (OVX) or oophorectomy plus E2 (OVX + E2) replacement. We found that absence of E2 was associated with higher levels of PPARc and lower levels of Sirt1 most significantly in the old group. In addition, old mice responded better to E2 replacement in terms of reducing adipogenesis and PPARc expression as well as increasing levels of Sirt1 expression. Our findings represent a new understanding of the role of E2 in age-related bone loss, which could be mediated through the regulation of Sirt1 expression within the bone marrow. In addition, this evidence suggests that old individuals may show a better response to E2 administration in terms of reverting the high levels of marrow fat seen in age-related bone loss. |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 27% |
| Researcher | 12 | 22% |
| Student > Master | 7 | 13% |
| Student > Bachelor | 4 | 7% |
| Professor | 4 | 7% |
| Other | 7 | 13% |
| Unknown | 6 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 35% |
| Medicine and Dentistry | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 7 | 13% |
| Engineering | 5 | 9% |
| Arts and Humanities | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 13 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2009.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from Biogerontology
#276
of 646 outputs
Outputs of similar age
#33,011
of 94,071 outputs
Outputs of similar age from Biogerontology
#4
of 5 outputs
Altmetric has tracked 22,787,797 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 646 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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