| Title |
Cloning and characterization of a second human NRAMP gene on chromosome 12q13
|
|---|---|
| Published in |
Mammalian Genome, April 1995
|
| DOI | 10.1007/bf00352405 |
| Pubmed ID | |
| Authors |
S. Vidal, A. -M. Belouchi, M. Cellier, B. Beatty, P. Gros |
| Abstract |
The mouse Nramp1 gene was initially identified by positional cloning as a candidate for the host resistance locus Bcg on mouse Chromosome (Chr) 1. Subsequent studies have shown that Nramp is a small gene family of at least three members in the mouse genome. We report the isolation and characterization of a cDNA clone corresponding to the second member of the human NRAMP family, NRAMP2. Predicted amino acid sequence analysis of the NRAMP2 polypeptide identifies a polytopic membrane protein highly homologous to NRAMP1, with 66% identical residues (80% overall homology), resulting in identical predicted secondary structures for the two proteins. Sequence conservation is particularly high in the predicted transmembrane domains (90%), suggesting that these regions play a key role in the structural and functional aspects common to both proteins. As opposed to its NRAMP1 counterpart, whose expression is restricted to phagocytic cells, Northern blotting analyses indicate that NRAMP2 mRNA transcripts are expressed at low levels in all tissues analyzed. Fluorescence in situ hybridization has identified 12q13 as the chromosomal location for human NRAMP2. |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 6% |
| Unknown | 17 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 22% |
| Professor > Associate Professor | 4 | 22% |
| Student > Bachelor | 2 | 11% |
| Student > Master | 2 | 11% |
| Professor | 2 | 11% |
| Other | 3 | 17% |
| Unknown | 1 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 56% |
| Medicine and Dentistry | 3 | 17% |
| Agricultural and Biological Sciences | 2 | 11% |
| Chemistry | 1 | 6% |
| Unknown | 2 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2018.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from Mammalian Genome
#318
of 1,126 outputs
Outputs of similar age
#7,527
of 25,099 outputs
Outputs of similar age from Mammalian Genome
#5
of 20 outputs
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