| Title |
miR-17–92 cluster: ups and downs in cancer and aging
|
|---|---|
| Published in |
Biogerontology, May 2010
|
| DOI | 10.1007/s10522-010-9272-9 |
| Pubmed ID | |
| Authors |
Johannes Grillari, Matthias Hackl, Regina Grillari-Voglauer |
| Abstract |
The miR-17-92 cluster encoding 6 single mature miRNAs was identified a couple of years ago to contain the first oncogenic miRNAs. Now, one of these 6 miRNAs, miR-19 has been identified as the key responsible for this oncogenic activity. This in turn reduces PTEN levels and in consequence activates the AKT/mTOR pathway that is also prominently involved in modulation of organismal life spans. In contrast, miR-19 and other members of the miR-17-92 cluster are found to be commonly downregulated in several human replicative and organismal aging models. Taken together, these findings suggest that miR-19 and the other members of the miR-17-92 cluster might be important regulators on the cross-roads between aging and cancer. Therefore, we here briefly summarize how this cluster is transcriptionally regulated, which target mRNAs have been confirmed so far and how this might be linked to modulation of organismal life-spans. |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 3 | 3% |
| United Kingdom | 2 | 2% |
| France | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 106 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 23% |
| Researcher | 26 | 23% |
| Student > Master | 15 | 13% |
| Student > Bachelor | 9 | 8% |
| Student > Postgraduate | 7 | 6% |
| Other | 19 | 17% |
| Unknown | 12 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 34% |
| Biochemistry, Genetics and Molecular Biology | 34 | 30% |
| Medicine and Dentistry | 11 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Neuroscience | 3 | 3% |
| Other | 8 | 7% |
| Unknown | 14 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2013.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from Biogerontology
#276
of 646 outputs
Outputs of similar age
#34,468
of 95,459 outputs
Outputs of similar age from Biogerontology
#4
of 6 outputs
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So far Altmetric has tracked 646 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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