Title |
MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neureceptor status in breast cancer
|
---|---|
Published in |
Breast Cancer Research, May 2009
|
DOI | 10.1186/bcr2257 |
Pubmed ID | |
Authors |
Aoife J Lowery, Nicola Miller, Amanda Devaney, Roisin E McNeill, Pamela A Davoren, Christophe Lemetre, Vladimir Benes, Sabine Schmidt, Jonathon Blake, Graham Ball, Michael J Kerin |
Abstract |
Breast cancer is a heterogeneous disease encompassing a number of phenotypically diverse tumours. Expression levels of the oestrogen, progesterone and HER2/neu receptors which characterize clinically distinct breast tumours have been shown to change during disease progression and in response to systemic therapies. Mi(cro)RNAs play critical roles in diverse biological processes and are aberrantly expressed in several human neoplasms including breast cancer, where they function as regulators of tumour behaviour and progression. The aims of this study were to identify miRNA signatures that accurately predict the oestrogen receptor (ER), progesterone receptor (PR) and HER2/neu receptor status of breast cancer patients to provide insight into the regulation of breast cancer phenotypes and progression. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 3 | 1% |
United States | 3 | 1% |
Spain | 2 | <1% |
Latvia | 1 | <1% |
Australia | 1 | <1% |
Malaysia | 1 | <1% |
Sweden | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Other | 5 | 2% |
Unknown | 270 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 71 | 25% |
Student > Ph. D. Student | 47 | 16% |
Student > Master | 31 | 11% |
Student > Bachelor | 25 | 9% |
Student > Doctoral Student | 19 | 7% |
Other | 59 | 20% |
Unknown | 37 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 100 | 35% |
Medicine and Dentistry | 62 | 21% |
Biochemistry, Genetics and Molecular Biology | 50 | 17% |
Computer Science | 12 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 1% |
Other | 12 | 4% |
Unknown | 49 | 17% |