Title |
Recent Advances in Animal Models of Zika Virus Infection
|
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Published in |
Virologica Sinica, March 2018
|
DOI | 10.1007/s12250-018-0007-4 |
Pubmed ID | |
Authors |
Shupeng Dong, Qiming Liang |
Abstract |
An infection by Zika virus (ZIKV), a mosquito-borne flavivirus, broke out in South American regions in 2015, and recently showed a tendency of spreading to North America and even worldwide. ZIKV was first detected in 1947 and only 14 human infection cases were reported until 2007. This virus was previously observed to cause only mild flu-like symptoms. However, recent ZIKV infections might be responsible for the increasing cases of neurological disorders such as Guillain-Barré syndrome and congenital defects, including newborn microcephaly. Therefore, researchers have established several animal models to study ZIKV transmission and pathogenesis, and test therapeutic candidates. This review mainly summarizes the reported animal models of ZIKV infection, including mice and non-human primates. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
United Kingdom | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 74 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 17 | 23% |
Researcher | 12 | 16% |
Student > Master | 11 | 15% |
Student > Doctoral Student | 7 | 9% |
Student > Ph. D. Student | 6 | 8% |
Other | 10 | 14% |
Unknown | 11 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 18% |
Immunology and Microbiology | 13 | 18% |
Biochemistry, Genetics and Molecular Biology | 13 | 18% |
Agricultural and Biological Sciences | 12 | 16% |
Social Sciences | 3 | 4% |
Other | 6 | 8% |
Unknown | 14 | 19% |