| Title |
Role of zinc and copper ions in the pathogenetic mechanisms of Alzheimer’s and Parkinson’s diseases
|
|---|---|
| Published in |
Biochemistry, May 2014
|
| DOI | 10.1134/s0006297914050022 |
| Pubmed ID | |
| Authors |
E. V. Stelmashook, N. K. Isaev, E. E. Genrikhs, G. A. Amelkina, L. G. Khaspekov, V. G. Skrebitsky, S. N. Illarioshkin |
| Abstract |
Disbalance of zinc (Zn2+) and copper (Cu2+) ions in the central nervous system is involved in the pathogenesis of numerous neurodegenerative disorders such as multisystem atrophy, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, Wilson-Konovalov disease, Alzheimer's disease, and Parkinson's disease. Among these, Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent age-related neurodegenerative pathologies with disorders in Zn2+ and Cu2+ homeostasis playing a pivotal role in the mechanisms of pathogenesis. In this review we generalized and systematized current literature data concerning this problem. The interactions of Zn2+ and Cu2+ with amyloid precursor protein (APP), β-amyloid (Abeta), tau-protein, metallothioneins, and GSK3β are considered, as well as the role of these interactions in the generation of free radicals in AD and PD. Analysis of the literature suggests that the main factors of AD and PD pathogenesis (oxidative stress, structural disorders and aggregation of proteins, mitochondrial dysfunction, energy deficiency) that initiate a cascade of events resulting finally in the dysfunction of neuronal networks are mediated by the disbalance of Zn2+ and Cu2+. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Egypt | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Colombia | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 109 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 19% |
| Student > Bachelor | 18 | 16% |
| Student > Master | 17 | 15% |
| Researcher | 13 | 12% |
| Student > Doctoral Student | 8 | 7% |
| Other | 17 | 15% |
| Unknown | 18 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 15% |
| Chemistry | 15 | 13% |
| Agricultural and Biological Sciences | 14 | 13% |
| Neuroscience | 13 | 12% |
| Biochemistry, Genetics and Molecular Biology | 11 | 10% |
| Other | 16 | 14% |
| Unknown | 26 | 23% |
Attention Score in Context
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#22,758,309
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Outputs from Biochemistry
#21,449
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#209,317
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Outputs of similar age from Biochemistry
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