Title |
Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models
|
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Published in |
Pflügers Archiv - European Journal of Physiology, March 2018
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DOI | 10.1007/s00424-018-2123-2 |
Pubmed ID | |
Authors |
Cristina Mammucari, Anna Raffaello, Denis Vecellio Reane, Gaia Gherardi, Agnese De Mario, Rosario Rizzuto |
Abstract |
Mitochondrial Ca2+is involved in heterogeneous functions, ranging from the control of metabolism and ATP production to the regulation of cell death. In addition, mitochondrial Ca2+uptake contributes to cytosolic [Ca2+] shaping thus impinging on specific Ca2+-dependent events. Mitochondrial Ca2+concentration is controlled by influx and efflux pathways: the former controlled by the activity of the mitochondrial Ca2+uniporter (MCU), the latter by the Na+/Ca2+exchanger (NCLX) and the H+/Ca2+(mHCX) exchanger. The molecular identities of MCU and of NCLX have been recently unraveled, thus allowing genetic studies on their physiopathological relevance. After a general framework on the significance of mitochondrial Ca2+uptake, this review discusses the structure of the MCU complex and the regulation of its activity, the importance of mitochondrial Ca2+signaling in different physiological settings, and the consequences of MCU modulation on organ physiology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 152 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 20% |
Researcher | 26 | 17% |
Student > Master | 15 | 10% |
Student > Bachelor | 13 | 9% |
Student > Doctoral Student | 5 | 3% |
Other | 19 | 13% |
Unknown | 44 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 55 | 36% |
Agricultural and Biological Sciences | 13 | 9% |
Neuroscience | 11 | 7% |
Medicine and Dentistry | 7 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Other | 13 | 9% |
Unknown | 47 | 31% |