| Title |
Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, March 2018
|
| DOI | 10.1007/s00424-018-2123-2 |
| Pubmed ID | |
| Authors |
Cristina Mammucari, Anna Raffaello, Denis Vecellio Reane, Gaia Gherardi, Agnese De Mario, Rosario Rizzuto |
| Abstract |
Mitochondrial Ca2+is involved in heterogeneous functions, ranging from the control of metabolism and ATP production to the regulation of cell death. In addition, mitochondrial Ca2+uptake contributes to cytosolic [Ca2+] shaping thus impinging on specific Ca2+-dependent events. Mitochondrial Ca2+concentration is controlled by influx and efflux pathways: the former controlled by the activity of the mitochondrial Ca2+uniporter (MCU), the latter by the Na+/Ca2+exchanger (NCLX) and the H+/Ca2+(mHCX) exchanger. The molecular identities of MCU and of NCLX have been recently unraveled, thus allowing genetic studies on their physiopathological relevance. After a general framework on the significance of mitochondrial Ca2+uptake, this review discusses the structure of the MCU complex and the regulation of its activity, the importance of mitochondrial Ca2+signaling in different physiological settings, and the consequences of MCU modulation on organ physiology. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 151 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 20% |
| Researcher | 26 | 17% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 13 | 9% |
| Professor | 5 | 3% |
| Other | 18 | 12% |
| Unknown | 44 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 54 | 36% |
| Agricultural and Biological Sciences | 13 | 9% |
| Neuroscience | 11 | 7% |
| Medicine and Dentistry | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 12 | 8% |
| Unknown | 48 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2021.
All research outputs
#15,510,692
of 23,818,521 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#1,339
of 1,973 outputs
Outputs of similar age
#204,658
of 335,343 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#6
of 17 outputs
Altmetric has tracked 23,818,521 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,973 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,343 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.