Title |
The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition
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Published in |
Genome Biology, August 2008
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DOI | 10.1186/gb-2008-9-8-r127 |
Pubmed ID | |
Authors |
Nicole Cloonan, Mellissa K Brown, Anita L Steptoe, Shivangi Wani, Wei Ling Chan, Alistair RR Forrest, Gabriel Kolle, Brian Gabrielli, Sean M Grimmond |
Abstract |
MicroRNAs are modifiers of gene expression, acting to reduce translation through either translational repression or mRNA cleavage. Recently, it has been shown that some microRNAs can act to promote or suppress cell transformation, with miR-17-92 described as the first oncogenic microRNA. The association of miR-17-92 encoded microRNAs with a surprisingly broad range of cancers not only underlines the clinical significance of this locus, but also suggests that miR-17-92 may regulate fundamental biological processes, and for these reasons miR-17-92 has been considered as a therapeutic target. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
Spain | 2 | 1% |
Australia | 1 | <1% |
India | 1 | <1% |
Malaysia | 1 | <1% |
United Kingdom | 1 | <1% |
Japan | 1 | <1% |
Poland | 1 | <1% |
Unknown | 141 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 36 | 24% |
Student > Ph. D. Student | 35 | 23% |
Student > Master | 19 | 12% |
Professor > Associate Professor | 15 | 10% |
Student > Bachelor | 9 | 6% |
Other | 19 | 12% |
Unknown | 20 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 61 | 40% |
Biochemistry, Genetics and Molecular Biology | 30 | 20% |
Medicine and Dentistry | 20 | 13% |
Chemistry | 5 | 3% |
Neuroscience | 4 | 3% |
Other | 8 | 5% |
Unknown | 25 | 16% |