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X Demographics
Mendeley readers
Attention Score in Context
| Title |
SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer
|
|---|---|
| Published in |
RNA, April 2011
|
| DOI | 10.1261/rna.2528811 |
| Pubmed ID | |
| Authors |
Marjan E. Askarian-Amiri, Joanna Crawford, Juliet D. French, Chanel E. Smart, Martin A. Smith, Michael B. Clark, Kelin Ru, Tim R. Mercer, Ella R. Thompson, Sunil R. Lakhani, Ana C. Vargas, Ian G. Campbell, Melissa A. Brown, Marcel E. Dinger, John S. Mattick |
| Abstract |
Long noncoding RNAs (lncRNAs) are increasingly recognized to play major regulatory roles in development and disease. To identify novel regulators in breast biology, we identified differentially regulated lncRNAs during mouse mammary development. Among the highest and most differentially expressed was a transcript (Zfas1) antisense to the 5' end of the protein-coding gene Znfx1. In vivo, Zfas1 RNA is localized within the ducts and alveoli of the mammary gland. Zfas1 intronically hosts three previously undescribed C/D box snoRNAs (SNORDs): Snord12, Snord12b, and Snord12c. In contrast to the general assumption that noncoding SNORD-host transcripts function only as vehicles to generate snoRNAs, knockdown of Zfas1 in a mammary epithelial cell line resulted in increased cellular proliferation and differentiation, while not substantially altering the levels of the SNORDs. In support of an independent function, we also found that Zfas1 is extremely stable, with a half-life >16 h. Expression analysis of the SNORDs revealed these were expressed at different levels, likely a result of distinct structures conferring differential stability. While there is relatively low primary sequence conservation between Zfas1 and its syntenic human ortholog ZFAS1, their predicted secondary structures have similar features. Like Zfas1, ZFAS1 is highly expressed in the mammary gland and is down-regulated in breast tumors compared to normal tissue. We propose a functional role for Zfas1/ ZFAS1 in the regulation of alveolar development and epithelial cell differentiation in the mammary gland, which, together with its dysregulation in human breast cancer, suggests ZFAS1 as a putative tumor suppressor gene. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 4% |
| Hungary | 2 | 1% |
| United Kingdom | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 156 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 20% |
| Researcher | 32 | 19% |
| Student > Master | 16 | 10% |
| Student > Bachelor | 16 | 10% |
| Professor > Associate Professor | 13 | 8% |
| Other | 26 | 16% |
| Unknown | 30 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 31% |
| Biochemistry, Genetics and Molecular Biology | 51 | 31% |
| Medicine and Dentistry | 17 | 10% |
| Neuroscience | 3 | 2% |
| Nursing and Health Professions | 2 | 1% |
| Other | 8 | 5% |
| Unknown | 33 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2017.
All research outputs
#4,513,383
of 22,787,797 outputs
Outputs from RNA
#873
of 3,017 outputs
Outputs of similar age
#22,495
of 109,336 outputs
Outputs of similar age from RNA
#7
of 18 outputs
Altmetric has tracked 22,787,797 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,017 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,336 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.