| Title |
Quantitation of HDAC1 mRNA Expression in Invasive Carcinoma of the Breast*
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, November 2005
|
| DOI | 10.1007/s10549-005-6001-1 |
| Pubmed ID | |
| Authors |
Zhenhuan Zhang, Hiroko Yamashita, Tatsuya Toyama, Hiroshi Sugiura, Yoshiaki Ando, Keiko Mita, Maho Hamaguchi, Yasuo Hara, Shunzo Kobayashi, Hirotaka Iwase |
| Abstract |
Estrogen is well-established as a mitogenic factor implicated in the tumorigenesis and progression of breast cancer via its binding to the estrogen receptor alpha (ERalpha). Recent data indicate that chromatin inactivation mediated by histone deacetylation (HDAC) and DNA methylation is a critical component of ERalpha silencing in human breast cancer cells. The aim of this study was to determine the expression of the HDAC1 gene in malignant human breast tissue and to correlate our observations with available clinical information. In the present study, the level of expression of HDAC1 mRNA was assessed by LightCycler-based quantitative real-time reverse transcriptase (RT)-PCR analysis in 162 cases of invasive carcinoma of the breast. Associations between HDAC1 mRNA expression and different clinicopathological factors were sought. It was found that HDAC1 mRNA was expressed at significantly higher levels in tumors from patients over 50 years of age and in those tumors without axillary lymph node involvement, that are less than 2 cm, that are of a non-high histological grade, that are HER2 negative and that are ERalpha/PgR positive. Patients with tumors displaying high levels of HDAC1 mRNA expression tended to have a better prognosis in terms of both disease-free and overall survival. However, univariate and multivariate analysis did not show HDAC1 mRNA expression level to be an independent prognostic factor for either disease-free or overall survival. These results imply that HDAC1 mRNA expression could have potential as an endocrine response marker and may have prognostic implications for breast cancer progression. |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Portugal | 1 | <1% |
| Slovakia | 1 | <1% |
| Unknown | 142 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 30% |
| Student > Master | 23 | 16% |
| Student > Bachelor | 13 | 9% |
| Researcher | 10 | 7% |
| Other | 9 | 6% |
| Other | 21 | 14% |
| Unknown | 25 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 20% |
| Agricultural and Biological Sciences | 29 | 20% |
| Medicine and Dentistry | 25 | 17% |
| Chemistry | 23 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Other | 7 | 5% |
| Unknown | 30 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2023.
All research outputs
#4,791,680
of 23,151,189 outputs
Outputs from Breast Cancer Research and Treatment
#903
of 4,691 outputs
Outputs of similar age
#11,044
of 61,254 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#6
of 47 outputs
Altmetric has tracked 23,151,189 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,691 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 61,254 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.