| Title |
Neurexins and Neuroligins: Recent Insights from Invertebrates
|
|---|---|
| Published in |
Molecular Neurobiology, October 2011
|
| DOI | 10.1007/s12035-011-8213-1 |
| Pubmed ID | |
| Authors |
David Knight, Wei Xie, Gabrielle L. Boulianne |
| Abstract |
During brain development, each neuron must find and synapse with the correct pre- and postsynaptic partners. The complexity of these connections and the relatively large distances some neurons must send their axons to find the correct partners makes studying brain development one of the most challenging, and yet fascinating disciplines in biology. Furthermore, once the initial connections have been made, the neurons constantly remodel their dendritic and axonal arbours in response to changing demands. Neurexin and neuroligin are two cell adhesion molecules identified as important regulators of this process. The importance of these genes in the development and modulation of synaptic connectivity is emphasised by the observation that mutations in these genes in humans have been associated with cognitive disorders such as Autism spectrum disorders, Tourette syndrome and Schizophrenia. The present review will discuss recent advances in our understanding of the role of these genes in synaptic development and modulation, and in particular, we will focus on recent work in invertebrate models, and how these results relate to studies in mammals. |
Mendeley readers
The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| Germany | 3 | 1% |
| Belgium | 2 | <1% |
| Israel | 2 | <1% |
| Brazil | 2 | <1% |
| United States | 2 | <1% |
| Canada | 2 | <1% |
| Chile | 1 | <1% |
| Portugal | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 183 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 23% |
| Researcher | 32 | 16% |
| Student > Bachelor | 29 | 14% |
| Student > Master | 23 | 11% |
| Professor | 13 | 6% |
| Other | 33 | 16% |
| Unknown | 28 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 86 | 42% |
| Neuroscience | 39 | 19% |
| Biochemistry, Genetics and Molecular Biology | 17 | 8% |
| Medicine and Dentistry | 16 | 8% |
| Psychology | 6 | 3% |
| Other | 6 | 3% |
| Unknown | 34 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2024.
All research outputs
#7,626,291
of 23,243,271 outputs
Outputs from Molecular Neurobiology
#1,384
of 3,525 outputs
Outputs of similar age
#47,723
of 142,151 outputs
Outputs of similar age from Molecular Neurobiology
#6
of 16 outputs
Altmetric has tracked 23,243,271 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,525 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 54% of its peers.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.