| Title |
The bile salt export pump
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, October 2006
|
| DOI | 10.1007/s00424-006-0152-8 |
| Pubmed ID | |
| Authors |
Bruno Stieger, Yvonne Meier, Peter J. Meier |
| Abstract |
Canalicular secretion of bile salts mediated by the bile salt export pump Bsep constitutes the major driving force for the generation of bile flow. Bsep is a member of the B-family of the super family of ATP-binding cassette transporters and is classified as ABCB11. Bsep has a narrow substrate specificity, which is largely restricted to bile salts. Bsep is extensively regulated at the transcriptional and posttranscriptional level, which directly modulates canalicular bile formation. Pathophysiological alterations of Bsep by either inherited mutations or acquired processes such as inhibition by drugs or disease-related down regulation may lead to a wide spectrum of mild to severe forms of liver disease. Furthermore, many genetic variants of Bsep are known, some of which potentially render individuals susceptible to acquired forms of liver disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Portugal | 1 | <1% |
| Switzerland | 1 | <1% |
| India | 1 | <1% |
| France | 1 | <1% |
| Belgium | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 100 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 21% |
| Researcher | 22 | 20% |
| Student > Master | 19 | 17% |
| Student > Doctoral Student | 10 | 9% |
| Other | 7 | 6% |
| Other | 12 | 11% |
| Unknown | 16 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 27% |
| Medicine and Dentistry | 19 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 16% |
| Biochemistry, Genetics and Molecular Biology | 14 | 13% |
| Chemistry | 9 | 8% |
| Other | 6 | 6% |
| Unknown | 15 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2023.
All research outputs
#3,033,089
of 24,885,505 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#93
of 2,037 outputs
Outputs of similar age
#6,896
of 78,539 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#2
of 14 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,037 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,539 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.