| Title |
Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index
|
|---|---|
| Published in |
Journal of Endocrinological Investigation, September 2017
|
| DOI | 10.1007/s40618-017-0762-3 |
| Pubmed ID | |
| Authors |
R. A. Condorelli, A. E. Calogero, M. Di Mauro, L. M. Mongioi’, R. Cannarella, G. Rosta, S. La Vignera |
| Abstract |
Insulin resistance is a common feature among women with polycystic ovary syndrome (PCOS), especially in those patients with hyperandrogenism and chronic anovulation. PCOS women are at risk for developing metabolic syndrome, impaired glucose tolerance and type II diabetes mellitus (DM II). The aim of this review is to explore the existing knowledge of the interplay between androgen excess, pancreatic β-cell function, non-alcoholic fatty liver disease (NAFLD), intra-abdominal and subcutaneous (SC) abdominal adipocytes in PCOS, providing a better comprehension of the molecular mechanisms of diabetologic interest. A comprehensive MEDLINE(®) search was performed using relevant key terms for PCOS and DM II. Insulin-induced hyperandrogenism could impair pancreatic β-cell function, the SC abdominal adipocytes' lipid storage capacity, leading to intra-abdominal adipocyte hypertrophy and lipotoxicity, which in turn promotes insulin resistance, and could enhance NAFLD. Fetal hyperandrogenism exposure prompts to metabolic disorders. Treatment with flutamide showed to partially reverse insulin resistance. Metabolic impairment seems not to be dependent only on the total fat mass content and body weight in women with PCOS and might be ascribed to the androgen excess. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 89 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 16% |
| Student > Bachelor | 14 | 16% |
| Student > Ph. D. Student | 12 | 13% |
| Student > Master | 8 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 14 | 16% |
| Unknown | 22 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 31% |
| Biochemistry, Genetics and Molecular Biology | 16 | 18% |
| Agricultural and Biological Sciences | 5 | 6% |
| Nursing and Health Professions | 3 | 3% |
| Unspecified | 2 | 2% |
| Other | 9 | 10% |
| Unknown | 26 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2018.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Journal of Endocrinological Investigation
#1,381
of 1,622 outputs
Outputs of similar age
#288,015
of 327,461 outputs
Outputs of similar age from Journal of Endocrinological Investigation
#17
of 18 outputs
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