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Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults

Overview of attention for article published in Molecular Nutrition & Food Research, March 2018
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Title
Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults
Published in
Molecular Nutrition & Food Research, March 2018
DOI 10.1002/mnfr.201700785
Pubmed ID
Authors

Kaifeng Li, Lorraine Brennan, Jack F. Bloomfield, Dan J. Duff, Breige A. McNulty, Albert Flynn, Janette Walton, Michael J. Gibney, Anne P. Nugent

Abstract

This study examined to what extent plasma linoleic acid (LA) is modified by adiposity, and explored any association between plasma LA, demographics, dietary intakes, markers of metabolic health and haplotypes of the fatty acid desaturase (FADS) 1/2 genes. 820 participants with fasting blood samples from Irish National Adult Nutrition Survey were studied. Plasma fatty acids were determined using GC-MS. 15 SNPs of FADS 1/2 genes were genotyped. Plasma LA decreased while γ-linoleic acid and dihomo-γ-linoleic acid increased in overweight/obese participants (P ≤ 0.002). Participants in the highest quartile of plasma LA showed decreased plasma markers of de novo lipogenesis, insulin resistance and of inflammation (TNF-α, PAI-1) (P ≤ 0.005). Adiposity (waist circumference and body fat) was strongly inversely associated with plasma LA accounting for 11.8% of variance observed, which was followed by FADS1/2 haplotypes (3.9 %), quantity and quality of carbohydrate intakes (3.8 %), dietary PUFA intakes (3.7 %), systolic blood pressure (3.6 %) and age (3.2 %). Plasma LA was inversely associated with adiposity, followed by haplotypes of FADS1/2 genes, carbohydrate intakes and dietary PUFA intakes. The association observed between plasma LA and adiposity may be linked to decreased de novo lipogenesis, insulin resistance and inflammation. This article is protected by copyright. All rights reserved.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 22%
Student > Master 4 17%
Student > Ph. D. Student 3 13%
Student > Bachelor 1 4%
Librarian 1 4%
Other 2 9%
Unknown 7 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 17%
Sports and Recreations 3 13%
Medicine and Dentistry 2 9%
Nursing and Health Professions 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 4 17%
Unknown 8 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2018.
All research outputs
#15,139,659
of 24,477,448 outputs
Outputs from Molecular Nutrition & Food Research
#1,610
of 2,651 outputs
Outputs of similar age
#187,519
of 336,955 outputs
Outputs of similar age from Molecular Nutrition & Food Research
#33
of 68 outputs
Altmetric has tracked 24,477,448 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,651 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,955 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.