| Title |
Phylogenies of Developmentally Important Proteins Do Not Support the Hypothesis of Two Rounds of Genome Duplication Early in Vertebrate History
|
|---|---|
| Published in |
Journal of Molecular Evolution, May 1999
|
| DOI | 10.1007/pl00006499 |
| Pubmed ID | |
| Authors |
Austin L. Hughes |
| Abstract |
It has been proposed that two rounds of duplication of the entire genome (polyploidization) occurred early in vertebrate history (the 2R hypothesis); and the observation that certain gene families important in regulating development have four members in vertebrates, as opposed to one in Drosophila, has been adduced as evidence in support of this hypothesis. However, such a pattern of relationship can be taken as support of the 2R hypothesis only if (1) the four vertebrate genes can be shown to have diverged after the origin of vertebrates, and (2) the phylogeny of the four vertebrate genes (A-D) exhibits a topology of the form (AB) (CD), rather than (A) (BCD). In order to test the 2R hypothesis, I constructed phylogenies for nine protein families important in development. Only one showed a topology of the form (AB) (CD), and that received weak statistical support. In contrast, four phylogenies showed topologies of the form (A) (BCD) with statistically significant support. Furthermore, in two cases there was significant support for duplication of the vertebrate genes prior to the divergence of deuterostomes and protostomes: in one case there was significant support for duplication of the vertebrate genes at least prior to the divergence of vertebrates and urochordates, and in one case there was weak support for duplication of the vertebrate genes prior to the divergence of deuterostomes and protostomes. Taken together with other recently published phylogenies of developmentally important genes, these results provide strong evidence against the 2R hypothesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 4% |
| Korea, Republic of | 1 | 1% |
| Australia | 1 | 1% |
| Sweden | 1 | 1% |
| Colombia | 1 | 1% |
| Singapore | 1 | 1% |
| Mexico | 1 | 1% |
| Spain | 1 | 1% |
| Philippines | 1 | 1% |
| Other | 0 | 0% |
| Unknown | 68 | 86% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 15 | 19% |
| Researcher | 13 | 16% |
| Student > Ph. D. Student | 12 | 15% |
| Professor | 10 | 13% |
| Student > Master | 7 | 9% |
| Other | 14 | 18% |
| Unknown | 8 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 48 | 61% |
| Biochemistry, Genetics and Molecular Biology | 13 | 16% |
| Computer Science | 2 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Environmental Science | 1 | 1% |
| Other | 5 | 6% |
| Unknown | 9 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2014.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from Journal of Molecular Evolution
#492
of 1,477 outputs
Outputs of similar age
#11,892
of 36,586 outputs
Outputs of similar age from Journal of Molecular Evolution
#9
of 18 outputs
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