| Title |
The EGF-TM7 family: a postgenomic view
|
|---|---|
| Published in |
Immunogenetics, November 2003
|
| DOI | 10.1007/s00251-003-0625-2 |
| Pubmed ID | |
| Authors |
Mark J. Kwakkenbos, Else N. Kop, Martin Stacey, Mourad Matmati, Siamon Gordon, Hsi-Hsien Lin, Jörg Hamann |
| Abstract |
With the human and mouse genome projects now completed, the receptor repertoire of mammalian cells has finally been elucidated. The EGF-TM7 receptors are a family of class B seven-span transmembrane (TM7) receptors predominantly expressed by cells of the immune system. Within the large TM7 superfamily, the molecular structure and ligand-binding properties of EGF-TM7 receptors are unique. Derived from the processing of a single polypeptide, they are expressed at the cell surface as heterodimers consisting of a large extracellular region associated with a TM7 moiety. Through a variable number of N-terminal epidermal growth factor (EGF)-like domains, EGF-TM7 receptors interact with cellular ligands such as CD55 and chondroitin sulfate. Recent in vivo studies demonstrate a role of the EGF-TM7 receptor CD97 in leukocyte migration. The different number of EGF-TM7 genes in man compared with mice, the chimeric nature of EMR2 and the inactivation of human EMR4 point toward a still-evolving receptor family. Here we discuss the currently available information on this intriguing receptor family. |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Switzerland | 1 | 2% |
| Unknown | 52 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 22% |
| Student > Ph. D. Student | 11 | 20% |
| Professor | 7 | 13% |
| Student > Master | 5 | 9% |
| Student > Bachelor | 4 | 7% |
| Other | 11 | 20% |
| Unknown | 4 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 48% |
| Medicine and Dentistry | 9 | 17% |
| Biochemistry, Genetics and Molecular Biology | 8 | 15% |
| Chemistry | 3 | 6% |
| Computer Science | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 5 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2023.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Immunogenetics
#350
of 1,215 outputs
Outputs of similar age
#35,996
of 142,417 outputs
Outputs of similar age from Immunogenetics
#2
of 4 outputs
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