| Title |
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
|
|---|---|
| Published in |
Journal of Neural Transmission, October 2008
|
| DOI | 10.1007/s00702-008-0119-3 |
| Pubmed ID | |
| Authors |
Klaus-Peter Lesch, Nina Timmesfeld, Tobias J. Renner, Rebecca Halperin, Christoph Röser, T. Trang Nguyen, David W. Craig, Jasmin Romanos, Monika Heine, Jobst Meyer, Christine Freitag, Andreas Warnke, Marcel Romanos, Helmut Schäfer, Susanne Walitza, Andreas Reif, Dietrich A. Stephan, Christian Jacob |
| Abstract |
A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing approximately 500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability. |
Mendeley readers
The data shown below were compiled from readership statistics for 265 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 1% |
| Netherlands | 2 | <1% |
| United States | 2 | <1% |
| United Kingdom | 2 | <1% |
| Australia | 1 | <1% |
| South Africa | 1 | <1% |
| Iceland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 252 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 50 | 19% |
| Researcher | 45 | 17% |
| Student > Bachelor | 31 | 12% |
| Student > Master | 28 | 11% |
| Student > Doctoral Student | 26 | 10% |
| Other | 41 | 15% |
| Unknown | 44 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 68 | 26% |
| Medicine and Dentistry | 36 | 14% |
| Biochemistry, Genetics and Molecular Biology | 28 | 11% |
| Psychology | 28 | 11% |
| Neuroscience | 25 | 9% |
| Other | 27 | 10% |
| Unknown | 53 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2023.
All research outputs
#2,554,245
of 23,445,423 outputs
Outputs from Journal of Neural Transmission
#114
of 1,804 outputs
Outputs of similar age
#7,429
of 91,146 outputs
Outputs of similar age from Journal of Neural Transmission
#2
of 10 outputs
Altmetric has tracked 23,445,423 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,804 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 91,146 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.