| Title |
CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload
|
|---|---|
| Published in |
JACC: Basic to Translational Science, March 2018
|
| DOI | 10.1016/j.jacbts.2017.12.006 |
| Pubmed ID | |
| Authors |
Bindiya Patel, Shyam S. Bansal, Mohamed Ameen Ismahil, Tariq Hamid, Gregg Rokosh, Matthias Mack, Sumanth D. Prabhu |
| Abstract |
Although chronic inflammation is a central feature of heart failure (HF), the immune cell profiles differ with different underlying causes. This suggests that for immunomodulatory therapy in HF to be successful, it needs to be tailored to the specific etiology. Here, the authors demonstrate that monocyte-derived C-C chemokine receptor 2 (CCR2)+ macrophages infiltrate the heart early during pressure overload in mice, and that blocking this response either pharmacologically or with antibody-mediated CCR2+ monocyte depletion alleviates late pathological left ventricular remodeling and dysfunction, T-cell expansion, and cardiac fibrosis. Hence, suppression of CCR2+ monocytes/macrophages may be an important immunomodulatory therapeutic target to ameliorate pressure-overload HF. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 18% |
| United Kingdom | 2 | 9% |
| India | 1 | 5% |
| Poland | 1 | 5% |
| China | 1 | 5% |
| Belgium | 1 | 5% |
| Venezuela, Bolivarian Republic of | 1 | 5% |
| Colombia | 1 | 5% |
| Chile | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 8 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 59% |
| Science communicators (journalists, bloggers, editors) | 4 | 18% |
| Scientists | 3 | 14% |
| Practitioners (doctors, other healthcare professionals) | 2 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 138 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 20% |
| Student > Ph. D. Student | 26 | 19% |
| Student > Bachelor | 15 | 11% |
| Student > Doctoral Student | 11 | 8% |
| Student > Master | 9 | 7% |
| Other | 16 | 12% |
| Unknown | 33 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 23% |
| Biochemistry, Genetics and Molecular Biology | 29 | 21% |
| Agricultural and Biological Sciences | 16 | 12% |
| Immunology and Microbiology | 6 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 9 | 7% |
| Unknown | 43 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 81. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2021.
All research outputs
#527,622
of 25,382,440 outputs
Outputs from JACC: Basic to Translational Science
#38
of 799 outputs
Outputs of similar age
#12,295
of 351,830 outputs
Outputs of similar age from JACC: Basic to Translational Science
#2
of 14 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 799 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,830 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.