| Title |
Multiple sclerosis and autoimmune diseases
|
|---|---|
| Published in |
Journal of Neurology, March 2006
|
| DOI | 10.1007/s00415-006-0084-4 |
| Pubmed ID | |
| Authors |
A. Laroni, M. Calabrese, P. Perini, M. P. Albergoni, F. Ranzato, M. Tiberio, L. Battistin, P. Gallo |
| Abstract |
An autoimmune background is thought to characterize the families of multiple sclerosis (MS) patients, but disease patterns and HLA-DR association seem to vary considerably among different ethnic groups. We investigated the prevalence of autoimmune diseases in 245 MS patients and 245 age- and sex-matched normal controls (NC), originating from and living in North-east Italy, and their first degree relatives, using a case-control method. Further, HLA-DRB1 expression was analysed in MS and NC. The following significant findings were observed: 1) a significant excess of autoimmunity in first-degree relatives of MS patients (p = 0.000), 2) an association of MS with Type 1 diabetes mellitus (T1DM) (p = 0.02), 3) an increase in DR4 expression (namely DRB1*0401) in MS patients from families with multiple autoimmune pathology compared with reference MS patients (p=0.02) and NC (p=0.01). We conclude that the risk of autoimmune disease is higher in first-degree relatives of MS patients and that disease association and HLA-DR expression in North-east Italy differs from other geographic regions of Europe. |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 2% |
| Unknown | 42 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 23% |
| Researcher | 5 | 12% |
| Student > Master | 4 | 9% |
| Professor > Associate Professor | 3 | 7% |
| Student > Ph. D. Student | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 13 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 37% |
| Neuroscience | 5 | 12% |
| Agricultural and Biological Sciences | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Unspecified | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 13 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2008.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from Journal of Neurology
#1,774
of 4,475 outputs
Outputs of similar age
#24,552
of 71,498 outputs
Outputs of similar age from Journal of Neurology
#5
of 12 outputs
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