Title |
Cyclophosphamide-based combination therapies for autoimmunity
|
---|---|
Published in |
Neurological Sciences, August 2008
|
DOI | 10.1007/s10072-008-0947-9 |
Pubmed ID | |
Authors |
Paola Perini, Massimiliano Calabrese, Luciano Rinaldi, Paolo Gallo |
Abstract |
Immunomodulatory agent (IMA)-unresponsive multiple sclerosis (MS) can quickly evolve to a dramatic and irreversible disability. Treating these patients with appropriate immunosuppressive therapies can be a chance to arrest disease activity and progression. Cyclophosphamide (Cyc)-based intense immunosuppression has been successfully used to treat rapidly deteriorating, IMA-refractory MS patients. Therapeutic protocols combining Cyc and interferon beta (IFNbeta) have also been successfully applied to treat IFNbeta-unresponsive MS. The association of Cyc with other immunomodulatory drugs or monoclonal antibodies is currently being investigated in clinical trials aimed at treating severe forms of autoimmune diseases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 18% |
Researcher | 3 | 14% |
Professor > Associate Professor | 3 | 14% |
Student > Ph. D. Student | 2 | 9% |
Student > Doctoral Student | 1 | 5% |
Other | 4 | 18% |
Unknown | 5 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 32% |
Neuroscience | 4 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 23% |