| Title |
RUNX1/AML1: A Central Player in Hematopoiesis
|
|---|---|
| Published in |
International Journal of Hematology, October 2001
|
| DOI | 10.1007/bf02982057 |
| Pubmed ID | |
| Authors |
Tsukasa Okuda, Motohiro Nishimura, Mitsushige Nakao, Yasuko Fujitaa |
| Abstract |
It has been well established that a number of transcription factors play critical roles in regulating the fate of hematopoietic stem cell populations. One of them is the leukemia-associated transcription factor acute myeloid leukemia 1 (AML1; also known as runt-related transcription factor 1, or RUNX1). This gene was originally cloned from the breakpoint of the t(8;21) reciprocal chromosome translocation and was later recognized as one of the most frequent targets of leukemia-associated gene aberrations. Gene-targeting experiments revealed that transcriptionally active AML1 is essential for the establishment of definitive hematopoiesis. More specifically, this gene functions in the emergence of the hematopoietic progenitor cells from the hemogenic endothelium by budding in the aorta-gonad-mesonephros region, and its expression points to the sites with strong potential for the emergence of hematopoietic stem cells. This review discusses aspects of the biologic properties of AML1 in early hematopoietic development. |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Israel | 1 | 1% |
| Poland | 1 | 1% |
| Denmark | 1 | 1% |
| Unknown | 85 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 19% |
| Student > Master | 17 | 19% |
| Student > Ph. D. Student | 15 | 16% |
| Researcher | 10 | 11% |
| Student > Doctoral Student | 7 | 8% |
| Other | 5 | 5% |
| Unknown | 20 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 27% |
| Biochemistry, Genetics and Molecular Biology | 22 | 24% |
| Medicine and Dentistry | 7 | 8% |
| Neuroscience | 4 | 4% |
| Engineering | 3 | 3% |
| Other | 6 | 7% |
| Unknown | 24 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2019.
All research outputs
#4,696,396
of 22,787,797 outputs
Outputs from International Journal of Hematology
#118
of 1,392 outputs
Outputs of similar age
#6,744
of 42,787 outputs
Outputs of similar age from International Journal of Hematology
#1
of 6 outputs
Altmetric has tracked 22,787,797 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,392 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 42,787 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them