| Title |
Bottom-up approaches in synthetic biology and biomaterials for tissue engineering applications
|
|---|---|
| Published in |
Journal of Industrial Microbiology & Biotechnology, July 2018
|
| DOI | 10.1007/s10295-018-2027-3 |
| Pubmed ID | |
| Authors |
Mitchell S Weisenberger, Tara L Deans |
| Abstract |
Synthetic biologists use engineering principles to design and construct genetic circuits for programming cells with novel functions. A bottom-up approach is commonly used to design and construct genetic circuits by piecing together functional modules that are capable of reprogramming cells with novel behavior. While genetic circuits control cell operations through the tight regulation of gene expression, a diverse array of environmental factors within the extracellular space also has a significant impact on cell behavior. This extracellular space offers an addition route for synthetic biologists to apply their engineering principles to program cell-responsive modules within the extracellular space using biomaterials. In this review, we discuss how taking a bottom-up approach to build genetic circuits using DNA modules can be applied to biomaterials for controlling cell behavior from the extracellular milieu. We suggest that, by collectively controlling intrinsic and extrinsic signals in synthetic biology and biomaterials, tissue engineering outcomes can be improved. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 30% |
| France | 1 | 10% |
| United Kingdom | 1 | 10% |
| Turkey | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 50% |
| Scientists | 5 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 18% |
| Student > Bachelor | 10 | 15% |
| Student > Ph. D. Student | 8 | 12% |
| Professor | 3 | 4% |
| Professor > Associate Professor | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 23 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 28% |
| Agricultural and Biological Sciences | 7 | 10% |
| Chemistry | 7 | 10% |
| Engineering | 5 | 7% |
| Medicine and Dentistry | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 24 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2018.
All research outputs
#5,287,218
of 25,382,440 outputs
Outputs from Journal of Industrial Microbiology & Biotechnology
#248
of 1,612 outputs
Outputs of similar age
#93,724
of 341,606 outputs
Outputs of similar age from Journal of Industrial Microbiology & Biotechnology
#5
of 24 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,612 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,606 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.