| Title |
Sequence-based association analysis of HLA class I and II alleles in Japanese supports conservation of common haplotypes
|
|---|---|
| Published in |
Immunogenetics, July 1997
|
| DOI | 10.1007/s002510050262 |
| Pubmed ID | |
| Authors |
K. Tokunaga, Yoshihide Ishikawa, Atsuko Ogawa, Huiru Wang, Shigeki Mitsunaga, Satoshi Moriyama, Ling Lin, Makoto Bannai, Yoshihisa Watanabe, Kouichi Kashiwase, Hidenori Tanaka, Tatsuya Akaza, Kenji Tadokoro, Takeo Juji |
| Abstract |
Alleles of HLA-A, B, C, DRB1, DQB1, and DPB1 loci were fully determined in 117 healthy Japanese. A*2402, A*3303, A*1101, A*0201, B*4403, B*5201, Cw*0102, Cw*1403, Cw*0304, Cw*0702, Cw*0801, and Cw*1202 showed frequencies of over 10%. Multi-locus haplotype frequencies were estimated by the maximum likelihood method. Strength of association between C and B loci was comparable with that between DRB1 and DQB1 loci. Alleles unidentified by a serological method and having very similar nucleotide sequences (A2: A*0201, A*0206, A*0207, B61: B*4002, B*4006) were carried by different haplotypes. Several frequent five-locus haplotypes were identified including A*3303-Cw*1403-B*4403-DRB1(*)1302-DQB1(*)0604, and A*2402-Cw*1202-B*5201-DRB1(*)1502-DQB1(*)0601. These sequence-based haplotypes corresponded to serology-based common haplotypes which have already been described in Japanese. These findings indicate that common HLA haplotypes consist of particular sets of HLA alleles and that these haplotypes have been conserved through recent human evolution. |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 6% |
| Thailand | 1 | 6% |
| Brazil | 1 | 6% |
| Unknown | 13 | 81% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 25% |
| Researcher | 3 | 19% |
| Lecturer > Senior Lecturer | 2 | 13% |
| Other | 1 | 6% |
| Professor | 1 | 6% |
| Other | 3 | 19% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 31% |
| Medicine and Dentistry | 4 | 25% |
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Computer Science | 2 | 13% |
| Mathematics | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 2 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2013.
All research outputs
#5,446,629
of 25,373,627 outputs
Outputs from Immunogenetics
#146
of 1,215 outputs
Outputs of similar age
#4,292
of 28,362 outputs
Outputs of similar age from Immunogenetics
#2
of 11 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,215 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 77% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.